Zeng Hang, Bi Hui-Chang, Huang Min
Laboratory of Drug Metabolism and Pharmacokinetics, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China.
Yao Xue Xue Bao. 2011 Jul;46(7):773-9.
Drug metabolism will change significantly during inflammation, including the reduction of expression and activity of many drug metabolizing enzymes and transporters. Body would release a series of inflammatory cytokines which can regulate drug metabolizing enzymes. Recent studies have revealed that drug transporters are also regulated by the cytokines with obvious species difference. Mechanism studies show that several transcription factors play important roles during the signal pathways of regulation. This review focuses on the progress in the regulation of drug transporters during inflammation.
在炎症期间，药物代谢会发生显著变化，包括许多药物代谢酶和转运体的表达及活性降低。机体释放的一系列炎性细胞因子可调节药物代谢酶。近期研究表明，药物转运体也受细胞因子调节，且存在明显的种属差异。机制研究显示，几种转录因子在调节信号通路中发挥重要作用。本综述重点关注炎症期间药物转运体调节方面的进展。
