Yang Li-Xin, Li Xing-Cui, Liu Chao, Xiao Lei, Qin De-Hua, Chen Ruo-Yun
State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
Yao Xue Xue Bao. 2011 Jul;46(7):818-21.
The investigation on Salvia przewalskii Maxim was carried out to find the relationship of the constituents and their pharmacological activities. The isolation and purification were performed by various chromatographies such as silica gel, Sephadex LH-20, RP-C18 column chromatography, etc. Further investigation on the fraction of the 95% ethanol extract of Salvia przewalskii Maxim yielded przewalskin Y-1 (1), anhydride of tanshinone-II A (2), sugiol (3), epicryptoacetalide (4), cryptoacetalide (5), arucadiol (6), 1-dehydromiltirone (7), miltirone (8), cryptotanshinone (9), tanshinone II A (10) and isotanshinone-I (11). Their structures were elucidated by the spectral analysis such as NMR (Nuclear Magnetic Resonance) and MS (Mass Spectrometry). Compound 1 is a new compound. Compounds 4 and 5 are mirror isomers (1 : 3). Compounds 4, 5, 6, 8, 11 were isolated from Salvia przewalskii Maxim for the first time.
对 przewalskii 鼠尾草（Salvia przewalskii Maxim）进行了研究，以探寻其成分与药理活性之间的关系。通过硅胶、Sephadex LH - 20、RP - C18 柱色谱等各种色谱法进行分离和纯化。对 przewalskii 鼠尾草 95%乙醇提取物的馏分进一步研究，得到了 przewalskin Y - 1（1）、丹参酮 II A 酐（2）、苏乔醇（3）、表隐丹参内酯（4）、隐丹参内酯（5）、香蒲二醇（6）、1 - 脱氢米赤酮（7）、米赤酮（8）、隐丹参酮（9）、丹参酮 II A（10）和异丹参酮 - I（11）。通过核磁共振（NMR）和质谱（MS）等光谱分析确定了它们的结构。化合物 1 是一种新化合物。化合物 4 和 5 是对映异构体（1 : 3）。化合物 4、5、6、8、11 首次从 przewalskii 鼠尾草中分离得到。
