Rybakowska Iwona, Szreder Grzegorz, Kaletha Krystian, Barwina Małgorzata, Waldman Wojciech, Sein Anand Jacek
Zakład Biochemii i Fizjologii Klinicznej, Gdańskiego Uniwersytetu Medycznego.
Przegl Lek. 2011;68(8):486-7.
Reactive oxygen species, which plays a role in pathogenesis of many neurodegenerative diseases, seems to be important also in pathogenesis of the Parkinson's disease. Experiments performed recently, revealed in the cerebrum of patients suffering from this disease (induced by the oxidative stress) elevated levels of 3,4-dihydroxyphenylacetaldehyde (DOPAL)--a strong endogenous neurotoxin to dopamine neurons.
活性氧在许多神经退行性疾病的发病机制中起作用，在帕金森病的发病机制中似乎也很重要。最近进行的实验显示，在患有这种疾病（由氧化应激引起）的患者大脑中，3,4-二羟基苯乙醛（DOPAL）——一种对多巴胺神经元有强烈毒性的内源性神经毒素——的水平升高。
