Siems W, Gärtner C, Kranz D, Schneider W, Grune T, Schimke J, Gau S, Wege U, Gerber G
Institute of Biochemistry, School of Medicine (Charité), Humboldt University, Berlin, G.D.R.
Radiobiol Radiother (Berl). 1990;31(3):257-63.
Male Wistar-H-rats were exposed monthly to a 60cobalt-source low dose whole body irradiation (0.25 Gy, total dose: 4.5 Gy). The glutathione disulphide:total glutathione ratio, the concentration of thiobarbituric acid-reactive substances and the activities of glutathione peroxidase and glutathione transferase in eight different organs and blood were analysed. The low dose irradiation is accompanied by distinct peroxidative changes in organs. These oxidative loadings occur in the small intestine, the spleen and the kidneys. The measurements of glutathione status and of thiobarbituric acid-reactive substances are proposed as sensitive parameters for low dose radiation induced changes.
雄性Wistar-H大鼠每月接受一次60钴源低剂量全身照射（0.25 Gy，总剂量：4.5 Gy）。分析了八种不同器官和血液中的谷胱甘肽二硫化物：总谷胱甘肽比值、硫代巴比妥酸反应性物质浓度以及谷胱甘肽过氧化物酶和谷胱甘肽转移酶的活性。低剂量照射伴随着器官明显的过氧化变化。这些氧化负荷发生在小肠、脾脏和肾脏中。谷胱甘肽状态和硫代巴比妥酸反应性物质的测量被提议作为低剂量辐射诱导变化的敏感参数。
