Jendryczko A, Drózdz M
Department of Drug Chemistry and Analysis, Silesian Medical School, Sosnowiec, Poland.
Pol J Occup Med Environ Health. 1992;5(3):251-6.
Thie biological effect of low dose radiation is little known. In the current study male Wistar rats were exposed monthly to a 60Co-source low dose whole body irradiation (0.25 Gy, per 18 months; total dose: 4.5 Gy). The glutathione disulphide (GSSH): total glutathione (GSH) ratio, the concentration of thiobarbituric acid-reactive substances and the activities of glutathione peroxidase and glutathione transferase in: small intestine, spleen, kidney, soleus muscle, and liver were analysed. Low dose irradiation is accompanied by distinct peroxidative changes in organs, observed in the small intestine, the spleen and in the kidneys. The current study suggests that the measurement of glutathione status and thiobarbituric acid-reactive substances can be proposed as sensitive parameters for low dose radiation induced changes.
低剂量辐射的生物学效应鲜为人知。在本研究中，雄性Wistar大鼠每月接受一次60Co源低剂量全身照射（每18个月0.25 Gy；总剂量：4.5 Gy）。分析了小肠、脾脏、肾脏、比目鱼肌和肝脏中谷胱甘肽二硫化物（GSSH）与总谷胱甘肽（GSH）的比值、硫代巴比妥酸反应性物质的浓度以及谷胱甘肽过氧化物酶和谷胱甘肽转移酶的活性。低剂量照射伴随着器官明显的过氧化变化，在小肠、脾脏和肾脏中均可观察到。本研究表明，谷胱甘肽状态和硫代巴比妥酸反应性物质的测量可作为低剂量辐射诱导变化的敏感参数。
