Raghupathy Ramesh, Witzenburg Colleen, Lake Spencer P, Sander Edward A, Barocas Victor H
Department of Mechanical Engineering, University of Minnesota, Minneapolis, MN 55455, USA.
J Biomech Eng. 2011 Sep;133(9):091011. doi: 10.1115/1.4005170.
In a previous work (Raghupathy and Barocas, 2010, "Generalized Anisotropic Inverse Mechanics for Soft Tissues,"J. Biomech. Eng., 132(8), pp. 081006), a generalized anisotropic inverse mechanics method applicable to soft tissues was presented and tested against simulated data. Here we demonstrate the ability of the method to identify regional differences in anisotropy from full-field displacements and boundary forces obtained from biaxial extension tests on soft tissue analogs. Tissue heterogeneity was evaluated by partitioning the domain into homogeneous subdomains. Tests on elastomer samples demonstrated the performance of the method on isotropic materials with uniform and nonuniform properties. Tests on fibroblast-remodeled collagen cruciforms indicated a strong correlation between local structural anisotropy (measured by polarized light microscopy) and the evaluated local mechanical anisotropy. The results demonstrate the potential to quantify regional anisotropic material behavior on an intact tissue sample.
在之前的一项工作中（Raghupathy和Barocas，2010年，“软组织的广义各向异性逆力学”，《生物力学工程杂志》，132(8)，第081006页），提出了一种适用于软组织的广义各向异性逆力学方法，并针对模拟数据进行了测试。在此，我们展示了该方法根据从软组织类似物的双轴拉伸试验获得的全场位移和边界力来识别各向异性区域差异的能力。通过将域划分为均匀子域来评估组织异质性。对弹性体样品的测试证明了该方法在具有均匀和非均匀特性的各向同性材料上的性能。对成纤维细胞重塑的胶原十字形的测试表明，局部结构各向异性（通过偏振光显微镜测量）与评估的局部力学各向异性之间存在很强的相关性。结果证明了在完整组织样本上量化区域各向异性材料行为的潜力。
