Department of Epidemiology, West China School of Public Health, Sichuan University, Chengdu, PR China.
DNA Cell Biol. 2012 May;31(5):688-99. doi: 10.1089/dna.2011.1403. Epub 2011 Oct 19.
SULT1A1 is involved in both detoxification of estrogens and bioactivation of carcinogens in smoked meat. SULT1A1 Arg213His polymorphism's effect on breast cancer risk is still unclear. We recruited 400 case-control pairs to investigate the association between SULT1A1 genotypes and breast cancer risk, and the combined effect of SULT1A1 polymorphism and daily intake of smoked meat. Participants were questioned about their dietary habits and other risk factors, and their SULT1A1 genotypes were determined. Adjusted odds ratios (aORs) and 95% confidence intervals (CIs) were estimated by multivariable unconditional logistic regression. We also performed a meta-analysis of relevant published studies to test these associations. In the case-control study, no significant associations were observed between SULT1A1 polymorphism and breast cancer risk. In the meta-analysis, SULT1A1 His/His genotype slightly increased risk among both overall and postmenopausal women (OR(pooled-overall)=1.12, 95% CI: 1.02-1.24; OR(pooled-post)=1.17, 95% CI: 1.03-1.32). A larger positive association was observed in Asian populations (OR(pooled-Asian)=2.01, 95% CI: 1.24-3.26). In our case-control study, high energy-adjusted daily intake of smoked meat was significantly associated with breast cancer risk in overall, pre- and postmenopausal women (aORs: 2.31-3.13, OR 95% CIs exclude 1). High smoked meat intake interacted positively with the His variant allele (all γ>1). These results correlated with those of the meta-analysis (γ(pooled-overall)=1.27). The SULT1A1 His/His genotype may increase the risk of breast cancer among Asian women, and dietary exposure to heterocyclic amines and polycyclic aromatic hydrocarbons, along with the SULT1A1 His/His variant genotype, may synergistically increase the risk of breast cancer.
SULT1A1 参与了雌激素的解毒和烟熏肉中致癌物质的生物活化。SULT1A1 Arg213His 多态性对乳腺癌风险的影响尚不清楚。我们招募了 400 对病例对照进行研究，调查了 SULT1A1 基因型与乳腺癌风险之间的关系，以及 SULT1A1 多态性与每日烟熏肉摄入量的联合作用。参与者被询问了他们的饮食习惯和其他风险因素，并且确定了他们的 SULT1A1 基因型。通过多变量非条件逻辑回归估计了调整后的比值比（aOR）和 95％置信区间（CI）。我们还对相关的已发表研究进行了荟萃分析，以检验这些关联。在病例对照研究中，SULT1A1 多态性与乳腺癌风险之间没有显著关联。在荟萃分析中，SULT1A1 His/His 基因型在总体和绝经后妇女中略微增加了风险（OR（汇总总体）=1.12，95％CI：1.02-1.24；OR（汇总绝经后）=1.17，95％CI：1.03-1.32）。在亚洲人群中观察到更大的正相关（OR（汇总亚洲）=2.01，95％CI：1.24-3.26）。在我们的病例对照研究中，高能量调整后的烟熏肉日摄入量与总体、绝经前和绝经后妇女的乳腺癌风险显著相关（aOR：2.31-3.13，OR 95％CI 排除 1）。高烟熏肉摄入量与 His 变异等位基因呈正交互作用（所有γ>1）。这些结果与荟萃分析的结果相关（γ（汇总）=1.27）。SULT1A1 His/His 基因型可能会增加亚洲女性患乳腺癌的风险，而饮食暴露于杂环胺和多环芳烃，以及 SULT1A1 His/His 变异基因型，可能会协同增加乳腺癌的风险。
