Department of Chemistry, University of Montana, Missoula, MT 59812, USA.
Dalton Trans. 2012 Jan 21;41(3):714-22. doi: 10.1039/c1dt11173f. Epub 2011 Oct 20.
This perspective report summarizes recent work on the interactions of the triosmium clusters of general formula Os(3)(CO)(9)(μ(3)-η(2)-L-H)(μ-H) (L = bicyclic benzoheterocycle) with DNA and proteins. The early work focused on how the structure of the benzoheterocycle influenced the binding of the cluster to plasmid DNA, albumin and the inhibition of telomerase. Later, selective binding of the triosmium clusters to guanine was targeted using a range of alkylating functionalities. In connection with these efforts some very recent unpublished work will be presented. Suggestions for future directions in this area and a summary of the problems and difficulties encountered will be discussed.
本观点报告总结了最近关于通式 Os(3)(CO)(9)(μ(3)-η(2)-L-H)(μ-H)（L = 双环苯并杂环）的三锇簇与 DNA 和蛋白质相互作用的研究工作。早期的工作重点是苯并杂环的结构如何影响簇与质粒 DNA、白蛋白的结合以及端粒酶的抑制。后来，使用一系列烷化官能团靶向三锇簇与鸟嘌呤的选择性结合。结合这些努力，将展示一些最近未发表的工作。将讨论该领域未来的发展方向以及遇到的问题和困难的总结。
