Pakulski Cezary
Department of Anaesthesiology, Intensive Therapy and Emergency Medicine, Pomeranian Medical University in Szczecin, ul. Unii Lubelskiej 1, 71-252 Szczecin.
Anestezjol Intens Ter. 2011 Jul-Sep;43(3):186-9.
Sex steroids play an important role in neuroprotection following brain injury. Although their protective action has been found to be effective in many experimental animal models, their use in humans remains controversial. Many authors have shown that the frequency and extent of post-ischaemic damage is sex-dependent, and even low concentrations of estrogens are neuroprotective, but not therapeutic. The authors have summarized the current knowledge of neuroprotection by sex steroids in experimental and clinical settings. They conclude that direct extrapolation from animals to humans is not possible, and so far, widespread clinical use of sex steroids in humans is not justified.
性类固醇在脑损伤后的神经保护中发挥着重要作用。尽管已发现它们的保护作用在许多实验动物模型中有效，但它们在人类中的应用仍存在争议。许多作者表明，缺血后损伤的频率和程度存在性别差异，即使低浓度的雌激素也具有神经保护作用，但并无治疗效果。作者总结了目前关于性类固醇在实验和临床环境中的神经保护作用的知识。他们得出结论，从动物直接推断到人类是不可能的，到目前为止，性类固醇在人类中的广泛临床应用尚无依据。
