性类固醇的神经保护作用。
Neuroprotection of sex steroids.
作者信息
Liu M, Kelley M H, Herson P S, Hurn P D
机构信息
Department of Anesthesiology and Perioperative Medicine, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA.
出版信息
Minerva Endocrinol. 2010 Jun;35(2):127-43.
Abstract
Sex steroids are essential for reproduction and development in animals and humans, and sex steroids also play an important role in neuroprotection following brain injury. New data indicate that sex-specific responses to brain injury occur at the cellular and molecular levels. This review summarizes the current understanding of neuroprotection by sex steroids, particularly estrogen, androgen, and progesterone, based on both in vitro and in vivo studies. Better understanding of the role of sex steroids under physiological and pathological conditions will help us to develop novel effective therapeutic strategies for brain injury.
摘要
性类固醇对动物和人类的生殖与发育至关重要，并且在脑损伤后的神经保护中也发挥着重要作用。新数据表明，在细胞和分子水平上存在对脑损伤的性别特异性反应。本综述基于体外和体内研究，总结了目前对性类固醇（尤其是雌激素、雄激素和孕激素）神经保护作用的认识。更好地理解性类固醇在生理和病理条件下的作用，将有助于我们开发针对脑损伤的新型有效治疗策略。
相似文献
1
Neuroprotection of sex steroids.
Minerva Endocrinol. 2010 Jun;35(2):127-43.
2
[The role of sex steroids in prevention of post-ischaemic brain injury].
Anestezjol Intens Ter. 2011 Jul-Sep;43(3):186-9.
3
Sex, sex steroids, and brain injury.
Semin Reprod Med. 2009 May;27(3):229-39. doi: 10.1055/s-0029-1216276. Epub 2009 Apr 28.
4
Neuroprotective Role of Steroidal Sex Hormones: An Overview.
CNS Neurosci Ther. 2016 May;22(5):342-50. doi: 10.1111/cns.12538. Epub 2016 Mar 25.
5
Role of Sex Steroids in β Cell Function, Growth, and Survival.
Trends Endocrinol Metab. 2016 Dec;27(12):844-855. doi: 10.1016/j.tem.2016.08.008. Epub 2016 Sep 15.
6
Regulation of astroglia by gonadal steroid hormones under physiological and pathological conditions.
Prog Neurobiol. 2016 Sep;144:5-26. doi: 10.1016/j.pneurobio.2016.06.002. Epub 2016 Jun 7.
7
Gender, sex steroids, and neuroprotection following traumatic brain injury.
J Head Trauma Rehabil. 2006 May-Jun;21(3):279-81. doi: 10.1097/00001199-200605000-00008.
8
Gender differences in acute CNS trauma and stroke: neuroprotective effects of estrogen and progesterone.
J Neurotrauma. 2000 May;17(5):367-88. doi: 10.1089/neu.2000.17.367.
9
Independent influences of sex steroids of systemic and central origin in a rat model of Parkinson's disease: A contribution to sex-specific neuroprotection by estrogens.
Horm Behav. 2010 Jan;57(1):23-34. doi: 10.1016/j.yhbeh.2009.06.002. Epub 2009 Jun 16.
10
Neuroprotective actions of sex steroids in Parkinson's disease.
Front Neuroendocrinol. 2009 Jul;30(2):142-57. doi: 10.1016/j.yfrne.2009.04.014. Epub 2009 May 3.
引用本文的文献
1
Systematic analysis of the burden of ischemic stroke attributable to high LDL-C from 1990 to 2021.
Front Neurol. 2025 Apr 4;16:1547714. doi: 10.3389/fneur.2025.1547714. eCollection 2025.
2
Age-related decline in blood-brain barrier function is more pronounced in males than females in parietal and temporal regions.
Elife. 2024 Nov 4;13:RP96155. doi: 10.7554/eLife.96155.
3
Gut-Brain Axis: Focus on Sex Differences in Neuroinflammation.
Int J Mol Sci. 2024 May 15;25(10):5377. doi: 10.3390/ijms25105377.
4
Age-Related Decline in Blood-Brain Barrier Function is More Pronounced in Males than Females in Parietal and Temporal Regions.
bioRxiv. 2024 Jun 11:2024.01.12.575463. doi: 10.1101/2024.01.12.575463.
5
Estrogen and psychosis - a review and future directions.
Arch Womens Ment Health. 2024 Dec;27(6):877-885. doi: 10.1007/s00737-023-01409-x. Epub 2024 Jan 15.
6
Gender Differences in Oxidative Stress in Relation to Cancer Susceptibility and Survival.
Antioxidants (Basel). 2023 Jun 11;12(6):1255. doi: 10.3390/antiox12061255.
7
Role of Loci (rs28757157 and rs3751591) with Ischemic Stroke Risk in the Chinese Han Population.
Pharmgenomics Pers Med. 2023 May 29;16:491-502. doi: 10.2147/PGPM.S404160. eCollection 2023.
8
Influence of sex, age and diabetes on brain transcriptome and proteome modifications following cerebral ischemia.
BMC Neurosci. 2023 Jan 27;24(1):7. doi: 10.1186/s12868-023-00775-7.
9
Progesterone Reduces ATP-Induced Pyroptosis of SH-SY5Y Cells.
Biomed Res Int. 2022 Aug 12;2022:4827444. doi: 10.1155/2022/4827444. eCollection 2022.
10
Medication use and risk of amyotrophic lateral sclerosis-a systematic review.
BMC Med. 2022 Aug 5;20(1):251. doi: 10.1186/s12916-022-02442-w.
本文引用的文献
1
Neuroprotective effects of progesterone following stroke in aged rats.
Behav Brain Res. 2010 May 1;209(1):119-22. doi: 10.1016/j.bbr.2010.01.026. Epub 2010 Jan 28.
2
Estrogen-receptor-mediated protection of cerebral endothelial cell viability and mitochondrial function after ischemic insult in vitro.
J Cereb Blood Flow Metab. 2010 Mar;30(3):545-54. doi: 10.1038/jcbfm.2009.226. Epub 2009 Oct 28.
3
Progesterone with vitamin D affords better neuroprotection against excitotoxicity in cultured cortical neurons than progesterone alone.
Mol Med. 2009 Sep-Oct;15(9-10):328-36. doi: 10.2119/molmed.2009.00016. Epub 2009 Jun 26.
4
Mechanisms of gender-linked ischemic brain injury.
Restor Neurol Neurosci. 2009;27(3):163-79. doi: 10.3233/RNN-2009-0467.
5
Role of soluble epoxide hydrolase in the sex-specific vascular response to cerebral ischemia.
J Cereb Blood Flow Metab. 2009 Aug;29(8):1475-81. doi: 10.1038/jcbfm.2009.65. Epub 2009 May 27.
6
Dose-dependent effects of androgens on outcome after focal cerebral ischemia in adult male mice.
J Cereb Blood Flow Metab. 2009 Aug;29(8):1454-62. doi: 10.1038/jcbfm.2009.60. Epub 2009 May 13.
7
Sex, sex steroids, and brain injury.
Semin Reprod Med. 2009 May;27(3):229-39. doi: 10.1055/s-0029-1216276. Epub 2009 Apr 28.
8
Lower testosterone levels predict incident stroke and transient ischemic attack in older men.
J Clin Endocrinol Metab. 2009 Jul;94(7):2353-9. doi: 10.1210/jc.2008-2416. Epub 2009 Apr 7.
9
Progesterone exerts neuroprotective effects by inhibiting inflammatory response after stroke.
Inflamm Res. 2009 Sep;58(9):619-24. doi: 10.1007/s00011-009-0032-8. Epub 2009 Mar 31.
10
17beta-estradiol protects against hypoxic/ischemic white matter damage in the neonatal rat brain.
J Neurosci Res. 2009 Jul;87(9):2078-86. doi: 10.1002/jnr.22023.
Zotero 插件