根据人体测量参数和细胞因子基因型调整后的老年女性血糖紊乱风险。

Risk of glycemic disorder in elderly women adjusted by anthropometric parameters and cytokine genotypes.

作者信息

Ferreira Aparecido Pimentel, Ferreira Cristiane Batisti, Souza Vinícius Carolino, Furioso Audrey Cecília Tonet, Toledo Juliana Oliveira, Moraes Clayton Franco, Córdova Cláudio, Nóbrega Otávio Tolêdo

机构信息

Núcleo Interdisciplinar de Pesquisa, ICESP/Faculdades Promove de Brasília, DF, Brazil.

出版信息

Rev Assoc Med Bras (1992). 2011 Sep-Oct;57(5):565-9. doi: 10.1590/s0104-42302011000500016.

DOI:10.1590/s0104-42302011000500016

PMID:22012292

Abstract

OBJECTIVE

The objective of the present study was to examine the association of glucose intolerance and type-2 diabetes mellitus with the -174 G > C and -308 G > A allelic variations of IL-6 and TNF-α, respectively, through anthropometric measurements and age strata.

METHODS

This is a cross-sectional study using data from 285 community dwelling elderly women who underwent physical, biochemical, and genetic examinations.

RESULT

Genotype-unadjusted analysis revealed that the risk of glucose intolerance and diabetes in elderly women with elevated BMI was 1.71 and 2.82 times higher, respectively, whereas age and conicity index did not show predictive value. Prevalence ratios for glucose intolerance and diabetes across allelic variants of IL-6 and TNF-α did not associate IL-6 with unbalanced glucose levels, despite adjustment for BMI, age, and conicity index. Conversely, carriers of the TNF-α A allele were 2.06 and 5.58 times more likely to exhibit glucose intolerance and diabetes, respectively, compared to GG homozygotes.

CONCLUSION

Our results suggest that bearing the A allele of the -308 G > A polymorphism of TNF-α predisposes to anthropometric measure-sensitive impaired glucose metabolism in older women.

摘要

目的

本研究的目的是通过人体测量和年龄分层，分别研究葡萄糖耐量异常和2型糖尿病与白细胞介素-6（IL-6）的-174 G＞C和肿瘤坏死因子-α（TNF-α）的-308 G＞A等位基因变异之间的关联。

方法

这是一项横断面研究，使用了285名接受了身体、生化和基因检查的社区老年女性的数据。

结果

未经基因型调整的分析显示，体重指数（BMI）升高的老年女性出现葡萄糖耐量异常和糖尿病的风险分别高出1.71倍和2.82倍，而年龄和锥度指数未显示出预测价值。尽管对BMI、年龄和锥度指数进行了调整，但IL-6和TNF-α等位基因变异的葡萄糖耐量异常和糖尿病患病率比值并未显示IL-6与血糖水平失衡有关。相反，与GG纯合子相比，TNF-α A等位基因携带者出现葡萄糖耐量异常和糖尿病的可能性分别高出2.06倍和5.58倍。