School of Mental Health, Jining Medical University, Jining, China.
Neuropsychopharmacology. 2012 Feb;37(3):677-84. doi: 10.1038/npp.2011.242. Epub 2011 Oct 19.
CACNA1C gene polymorphism (rs1006737) is a susceptibility factor for both schizophrenia (SCZ) and bipolar disorder (BP). However, its role in working memory, a cognitive function that is impaired in both diseases, is not clear. Using three samples, including healthy controls, patients with SCZ, and patients currently in manic episodes of BP, this study tested the association between the SNP rs1006737 and spatial working memory as measured by an N-back task and a dot pattern expectancy (DPX) task. Among SCZ patients and healthy controls, the clinical risk allele was associated with impaired working memory, but the association was either in opposite direction or non-significant in patients with BP. These results indicated that rs1006737 may have differential effects on working memory in different disease populations and pointed to the necessity for more studies in different patient populations.
CACNA1C 基因多态性（rs1006737）是精神分裂症（SCZ）和双相情感障碍（BP）的易感因素。然而，其在工作记忆中的作用，即两种疾病中受损的认知功能，尚不清楚。本研究使用三个样本，包括健康对照、SCZ 患者和目前处于 BP 躁狂发作的患者，测试了 SNP rs1006737 与空间工作记忆的关联，通过 N-back 任务和点模式预期（DPX）任务进行测量。在 SCZ 患者和健康对照组中，临床风险等位基因与工作记忆受损相关，但在 BP 患者中，这种关联要么方向相反，要么无统计学意义。这些结果表明，rs1006737 可能对不同疾病人群的工作记忆有不同的影响，并指出需要在不同的患者群体中进行更多的研究。
