University of Kentucky College of Nursing, Lexington, KY, USA.
Pediatr Blood Cancer. 2012 Jun;58(6):964-70. doi: 10.1002/pbc.23359. Epub 2011 Oct 19.
The growing number of childhood cancer survivors makes examination of their current physical and mental health status and health behaviors an important concern. Much of what is known about the long-term outcomes of childhood cancer survivors comes from the Childhood Cancer Cohort Study (CCSS) which uses sibling controls.
Using data from the 2009 Behavioral Risk Factor Surveillance System survey, 651 childhood cancer survivors and 142,932 non-cancer peer controls were identified. The two groups were compared on a variety of physical and mental health status and health behavior variables using ANCOVA and binary logistic regression.
While controlling for differences in age, sex, and minority status, survivors significantly (P ≤ 0.001) had poorer socioeconomic outcomes, more comorbid conditions, lower life satisfaction, less social and emotional support, poorer general health, and reported more days per month of poor physical and mental health than non-cancer individuals. Survivors were more likely to report being a current smoker [odds ratio (OR) = 2.33; 95% confidence interval (CI), 1.98-2.73; P < 0.001]; tested for human immunodeficiency virus (HIV) (OR = 1.79; 95% CI, 1.52-2.11; P < 0.001); and that at least one HIV situation applied to them (OR = 2.06; 95% CI, 1.55-2.74; P < 0.001). No significant differences were found between groups in regards alcohol use and diet.
Results support and extend previous findings reported by the CCSS. New findings regarding survivors' increased likelihood to engage in risky behaviors proposes new directions for future research.
随着儿童癌症幸存者人数的增加，对他们当前身心健康状况和健康行为的检查成为一个重要关注点。关于儿童癌症幸存者长期预后的大部分知识来自于儿童癌症队列研究（CCSS），该研究使用了同胞对照。
利用 2009 年行为风险因素监测系统调查的数据，确定了 651 名儿童癌症幸存者和 142932 名非癌症同龄对照。使用协方差分析和二项逻辑回归比较两组在各种身心健康状况和健康行为变量上的差异。
在控制年龄、性别和少数民族地位差异的情况下，幸存者在社会经济状况较差、合并症较多、生活满意度较低、社会和情感支持较少、一般健康状况较差以及报告每月有较多天数身心健康状况较差方面存在显著差异（P ≤ 0.001）。幸存者更有可能报告当前吸烟（优势比[OR] = 2.33；95%置信区间[CI]，1.98-2.73；P < 0.001）；接受人类免疫缺陷病毒（HIV）检测（OR = 1.79；95% CI，1.52-2.11；P < 0.001）；至少有一种 HIV 情况适用于他们（OR = 2.06；95% CI，1.55-2.74；P < 0.001）。在饮酒和饮食方面，两组之间没有显著差异。
结果支持并扩展了 CCSS 之前报告的发现。关于幸存者更有可能从事危险行为的新发现为未来研究提出了新的方向。
