Center for Biomaterial Development and Berlin-Brandenburg Center for Regenerative Therapies, Institute of Polymer Research, Helmholtz-Zentrum Geesthacht, Kantstrasse 55, 14513 Teltow, Germany.
Macromol Biosci. 2011 Dec 8;11(12):1637-46. doi: 10.1002/mabi.201100226. Epub 2011 Oct 19.
For polymer-based degradable implants, mechanical performance and degradation behavior need to be precisely controlled. Based on a rational design, this work comprehensively describes the properties of photo-crosslinked polymer networks prepared from poly(rac-lactide)-block-poly(propylene glycol)-block-poly(rac-lactide) dimethacrylate precursors during degradation. By varying the length of poly(rac-lactide) blocks connected to a central 4 kDa polyether block, microphase separated networks with adjustable crosslinking density, hydrophilicity/hydrophobicity ratio, thermal, and mechanical properties are obtained. The materials are characterized by a low water uptake, controlled mass loss, and slowly decreasing wet-state E moduli in the kPa range.
对于基于聚合物的可降解植入物，需要精确控制其机械性能和降解行为。基于合理的设计，这项工作全面描述了由聚（丙交酯-共-丙二醇-共-丙交酯）二甲基丙烯酸酯前体制备的光交联聚合物网络在降解过程中的性能。通过改变连接到中心 4 kDa 聚醚嵌段的聚（丙交酯）嵌段的长度，可以得到具有可调交联密度、亲水性/疏水性比、热和机械性能的微相分离网络。这些材料的特点是吸水率低、质量损失可控以及湿态下 E 模量在 kPa 范围内缓慢下降。
