可降解聚对苯二甲酸丁二醇酯/聚乙二醇（PBT/PEG）共聚物的合成、表征及水解降解

Synthesis, characterization and hydrolytic degradation of degradable poly(butylene terephthalate)/poly(ethylene glycol) (PBT/PEG) copolymers.

作者信息

Chao GuoTao, Fan LinYu, Jia WenJuan, Qian ZhiYong, Gu YingChun, Liu CaiBing, Ni XiPing, Li Jun, Deng HongXin, Gong ChangYang, Gou MaLing, Lei Ke, Huang AnLiang, Huang CanHua, Yang JinLiang, Kan Bing, Tu MingJing

机构信息

State key Laborotary of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, China,

出版信息

J Mater Sci Mater Med. 2007 Mar;18(3):449-55. doi: 10.1007/s10856-007-2004-2.

DOI:10.1007/s10856-007-2004-2

PMID:17334695

Abstract

Hydrolytic degradable PBT/PEG copolymer was synthesized by macromolecular transesterification method from PBT and PEG macromonomers. The resultant copolymers were characterized by (1)H-NMR and GPC. The non-isothermal crystallization behavior of these copolymers was studied by differential scanning calorimetry (DSC). The water absorption and hydrolytic degradation behavior of PBT/PEG copolymers were also studied in detail.

摘要

通过大分子酯交换法，由聚对苯二甲酸丁二醇酯（PBT）和聚乙二醇（PEG）大分子单体合成了水解可降解的PBT/PEG共聚物。通过核磁共振氢谱（¹H-NMR）和凝胶渗透色谱法（GPC）对所得共聚物进行了表征。采用差示扫描量热法（DSC）研究了这些共聚物的非等温结晶行为。还详细研究了PBT/PEG共聚物的吸水性和水解降解行为。