Herrero-Velázquez Sonia, Guerrero-Peral Ángel L, Mulero Patricia, Peñas-Martínez M Luz, Cortijo Elisa, Miranda Sara, Rojo-Martinez Esther, Henao Ana, Rodríguez Raquel, Pedraza María, Hurtado M Luisa, Marco-Llorente Javier, Fernández-Buey M Nieves, Fernández Rosa
Hospital Clinico Universitario de Valladolid, 47005 Valladolid, Espana.
Rev Neurol. 2011 Nov 1;53(9):531-7.
Epicrania fugax is a recently reported condition consisting in brief painful paroxysms that begin in the posterior regions of the brain and irradiate towards the ipsilateral eye, nose or temple.
To present 18 cases of epicrania fugax from a monographic headache centre in a tertiary hospital and to analyse their demographic and clinical features, as well as the indication and response to prophylactic treatment.
Between March 2008, when epicrania fugax was first reported, and March 2011, of a total of 1210 patients who were attended in that service (1.48%), 18 (12 females and 6 males) were diagnosed as suffering from this condition. Six of these cases had been published earlier.
The mean age at onset was 42.5 ± 17.7 years (range: 23-82 years). They presented painful paroxysms that began in the occipital (n = 11; 61.1%), parietal (n = 6; 33.3%) or parieto-occipital (n = 1; 5.6%) regions and irradiated towards the ipsilateral eye (n = 12; 66.6%) or temple (n = 6; 33.3%); the whole process lasted less than 15 seconds. Most of them described the pain as lancinating or stabbing. In 10 cases (55.5%) a pain remained in the area where the paroxysms began, which in 6 cases (33.3%) was limited to a well-defined circular area and met the criteria for classification as nummular headache. In 12 cases (66.6%), prophylactic treatment was used, above all lamotrigine and gabapentin, with varying results.
Our aim is to back the proposal of epicrania fugax as a new syndrome with a well-defined clinical spectrum. It does not appear to be an exceptional condition and further knowledge about it will probably give rise to the description of new series. Treatment is often necessary and, although further information and experience are needed, gabapentin and lamotrigine both play a promising role.
发作性偏头痛性神经痛是一种最近报道的病症,表现为始于脑后部区域的短暂性疼痛发作,并向同侧眼、鼻或颞部放射。
介绍一家三级医院专科头痛中心的18例发作性偏头痛性神经痛病例,并分析其人口统计学和临床特征,以及预防性治疗的适应证和反应。
在2008年3月(发作性偏头痛性神经痛首次被报道)至2011年3月期间,在该科室就诊的1210例患者中(占1.48%),有18例(12例女性和6例男性)被诊断为此病。其中6例病例此前已发表。
发病的平均年龄为42.5±17.7岁(范围:23 - 82岁)。他们表现为始于枕部(n = 11;61.1%)、顶叶(n = 6;33.3%)或顶枕部(n = 1;5.6%)区域的疼痛发作,并向同侧眼(n = 12;66.6%)或颞部(n = 6;33.3%)放射;整个过程持续不到15秒。他们大多将疼痛描述为刺痛或刀割样痛。10例患者(55.5%)在发作起始部位遗留疼痛,其中6例(33.3%)局限于一个界限清晰的圆形区域,符合钱币状头痛的分类标准。12例患者(66.6%)采用了预防性治疗,主要是拉莫三嗪和加巴喷丁,效果各异。
我们旨在支持将发作性偏头痛性神经痛作为一种具有明确临床谱的新综合征的提议。它似乎并非罕见病症,对其进一步了解可能会促使更多新病例系列的报道。通常需要进行治疗,尽管还需要更多信息和经验,但加巴喷丁和拉莫三嗪都显示出有前景的作用。