肝细胞癌的超声造影：廓清时间与血管生成的相关性。

Contrast-enhanced ultrasound of hepatocellular carcinoma: Correlation of washout time and angiogenesis.

机构信息

Department of Ultrasound, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences Beijing, China.

出版信息

Clin Hemorheol Microcirc. 2011;48(4):265-73. doi: 10.3233/CH-2011-1420.

DOI:10.3233/CH-2011-1420

PMID:22012832

Abstract

BACKGROUND

The use of the pure blood pool ultrasound contrast agent SonoVue (Bracco, Italy) with specific ultrasound imaging software has enabled the dynamic visualization of tumor microcirculation.

AIM

The present study was designed to investigate the washout time of hepatocellular carcinoma (HCC) and correlate it with angiogenesis parameters.

METHODS

Thirty-one surgically confirmed HCC cases were prospectively evaluated with contrast-enhanced ultrasound (CEUS), and parameters such as wash-in time, peak enhancement time and washout time were determined offline. We also calculated microvessel density and the percentage of microvessel area (MVA) and compared CEUS parameters between a well differentiated group and a poorly to moderately differentiated group. The Spearman rank order correlation method was used to analyze the relationship between washout time and angiogenesis parameters.

RESULTS

The washout time was longer in well differentiated HCC patients compared to those with poorly to moderately differentiated HCC (p < 0.05). In addition, the washout time of HCC was positively correlated with the percentage of MVA (r = 0.510).

CONCLUSIONS

Given that the percentage of MVA was positively correlated with tumor blood volume, washout time may be associated with HCC blood volume.

摘要

背景

使用纯血池超声造影剂 SonoVue（意大利 Bracco）和特定的超声成像软件，已经能够实现肿瘤微循环的动态可视化。

目的

本研究旨在探讨肝细胞癌（HCC）的洗脱时间，并将其与血管生成参数相关联。

方法

前瞻性评估 31 例手术证实的 HCC 患者的超声造影（CEUS），离线确定灌注时间、峰值增强时间和洗脱时间等参数。我们还计算了微血管密度和微血管面积百分比（MVA），并比较了高分化组和低分化至中分化组之间的 CEUS 参数。采用 Spearman 秩相关分析方法分析洗脱时间与血管生成参数之间的关系。