Department of Paediatric Neurology, Birmingham Children's Hospital, Birmingham, UK.
Mult Scler. 2012 May;18(5):679-82. doi: 10.1177/1352458511426815. Epub 2011 Oct 19.
The new McDonald 2010 criteria have been recommended in paediatric multiple sclerosis (PMS). We aimed to assess the utility of McDonald 2010 criteria in comparison with 2007 International Paediatric Multiple Sclerosis Study Group (IPMSSG)-recommended criteria for PMS diagnosis. Retrospective analysis of 38 PMS cases from three UK demyelination clinics was conducted. Dissemination in space (DIS) and time (DIT) for both McDonald and IPMSSG criteria were noted on initial and follow-up magnetic resonance imaging (MRI). At first MRI scan, IPMSSG DIS criteria were fulfilled in 68% of scans and McDonald DIS criteria in 84%. In total, 11/18 children given gadolinium contrast fulfilled both McDonald DIS and DIT criteria on initial scan. The 2010 McDonald criteria appear more sensitive than IPMSSG and may allow PMS diagnosis at first presentation of CIS in at least a half of cases.
新版 McDonald 标准已被推荐用于儿科多发性硬化症（PMS）的诊断。我们旨在评估 McDonald 2010 标准与 2007 年国际儿科多发性硬化症研究组（IPMSSG）推荐的 PMS 诊断标准相比的效用。对来自英国三家脱髓鞘疾病诊所的 38 例 PMS 病例进行了回顾性分析。在初始和随访磁共振成像（MRI）上记录了 McDonald 和 IPMSSG 标准的空间（DIS）和时间（DIT）传播。在首次 MRI 扫描中，68%的扫描符合 IPMSSG DIS 标准，84%的扫描符合 McDonald DIS 标准。在总共 18 名接受钆造影剂的儿童中，有 11 名儿童在初次扫描时同时符合 McDonald DIS 和 DIT 标准。2010 年 McDonald 标准比 IPMSSG 更敏感，至少可以在一半的 CIS 首次发作时诊断 PMS。
