Myasthenia gravis with antibodies to MuSK: another step toward solving mystery?

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作者信息

Evoli Amelia, Lindstrom Jon

出版信息

Neurology. 2011 Nov 15;77(20):1783-4. doi: 10.1212/WNL.0b013e3182377fa6. Epub 2011 Oct 19.

DOI:10.1212/WNL.0b013e3182377fa6

PMID:22013184

Abstract

摘要

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Myasthenia gravis with antibodies to MuSK: another step toward solving mystery?

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Collagen Q and anti-MuSK autoantibody competitively suppress agrin/LRP4/MuSK signaling.胶原蛋白Q和抗MuSK自身抗体竞争性抑制聚集蛋白/LRP4/MuSK信号传导。

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[Anti-MuSK antibodies in myasthenia gravis block binding of collagen Q to MuSK].重症肌无力中的抗肌肉特异性激酶抗体阻断胶原蛋白Q与肌肉特异性激酶的结合

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Collagen Q is a key player for developing rational therapy for congenital myasthenia and for dissecting the mechanisms of anti-MuSK myasthenia gravis.胶原蛋白Q是开发先天性肌无力合理疗法以及剖析抗MuSK重症肌无力机制的关键因素。

J Mol Neurosci. 2014 Jul;53(3):359-61. doi: 10.1007/s12031-013-0170-x.

MuSK is required for anchoring acetylcholinesterase at the neuromuscular junction.在神经肌肉接头处锚定乙酰胆碱酯酶需要MuSK。

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Single-fiber electromyography in limb and facial muscles in muscle-specific kinase antibody and acetylcholine receptor antibody myasthenia gravis.肌肉特异性激酶抗体和乙酰胆碱受体抗体重症肌无力患者肢体及面部肌肉的单纤维肌电图检查

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Developmental consequences of the ColQ/MuSK interactions.ColQ/MuSK 相互作用的发育后果。

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Two cases of thymoma-associated myasthenia gravis without antibodies to the acetylcholine receptor.两例无乙酰胆碱受体抗体的胸腺瘤相关性重症肌无力病例。

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Antibodies against Wnt receptor of muscle-specific tyrosine kinase in myasthenia gravis.重症肌无力患者肌肉特异性酪氨酸激酶 Wnt 受体抗体。

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引用本文的文献

Clinical pitfalls and serological diagnostics of MuSK myasthenia gravis.肉毒碱乙酰转移酶抗体阳性重症肌无力的临床误区与血清学诊断

J Neurol. 2023 Mar;270(3):1478-1486. doi: 10.1007/s00415-022-11458-4. Epub 2022 Nov 17.

Afterdischarges in Myasthenia Gravis.重症肌无力患者出院后。

Front Neurol. 2021 Apr 13;12:599744. doi: 10.3389/fneur.2021.599744. eCollection 2021.

MuSK-Associated Myasthenia Gravis: Clinical Features and Management.与肌肉特异性激酶相关的重症肌无力：临床特征与管理

Front Neurol. 2020 Jul 23;11:660. doi: 10.3389/fneur.2020.00660. eCollection 2020.

Muscle-Specific Kinase Myasthenia Gravis.肌肉特异性激酶重症肌无力。

Front Immunol. 2020 May 8;11:707. doi: 10.3389/fimmu.2020.00707. eCollection 2020.

MuSK EAMG: Immunological Characterization and Suppression by Induction of Oral Tolerance.肌肉特异性受体酪氨酸激酶肌炎的电诊断检查：免疫特征和口服耐受诱导的抑制作用。

Front Immunol. 2020 Mar 17;11:403. doi: 10.3389/fimmu.2020.00403. eCollection 2020.

Clinically biphasic myasthenia gravis with both AChR and MuSK antibodies.临床上为双相重症肌无力，同时存在乙酰胆碱受体（AChR）抗体和肌肉特异性激酶（MuSK）抗体。

J Neurol. 2012 Dec;259(12):2736-9. doi: 10.1007/s00415-012-6661-9. Epub 2012 Sep 7.

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