School of Clinical Medicine of Lanzhou University, People's Republic of China; Yale University School of Medicine, USA; Department of General Surgery of the Second Hospital of Lanzhou University, People's Republic of China.
Dose Response. 2011;9(3):356-68. doi: 10.2203/dose-response.10-015.Chen. Epub 2010 Aug 2.
The aim of this study was to examine the early effects of low dose (12)C(6+) irradiation or X-ray on peripheral blood lymphocytes (PBL) of patients with alimentary tract cancer and to explore mechanisms that may be involved in an antitumor immune response. We found that the percentage of T lymphocyte subsets, the mRNA expression levels of IL-2 and IFN-γ in PBL, and their protein levels in supernatant were significantly increased 24 hours after exposure to low dose radiation. The effects were more pronounced in the group receiving 0.05Gy (12)C(6+) ion irradiation than the group receiving X-ray irradiation. There was no significant change in the percentage of NK cell subsets and TNF-α production of PBL. Our study suggests that low dose irradiation could alleviate immune suppression caused by tumor burden and that the effect was more pronounced for 0.05Gy high linear energy transfer (LET) (12)C(6+) irradiation.
本研究旨在探讨低剂量（12)C(6+)辐照或 X 射线对消化道肿瘤患者外周血淋巴细胞（PBL）的早期影响，并探讨可能参与抗肿瘤免疫反应的机制。我们发现，暴露于低剂量辐射后 24 小时，PBL 中 T 淋巴细胞亚群的百分比、IL-2 和 IFN-γ 的 mRNA 表达水平及其上清液中的蛋白水平显著增加。接受 0.05Gy（12)C(6+)离子照射的组比接受 X 射线照射的组效果更明显。PBL 中 NK 细胞亚群的百分比和 TNF-α 的产生没有明显变化。我们的研究表明，低剂量照射可以减轻肿瘤负担引起的免疫抑制，而 0.05Gy 高线性能量转移（LET）（12)C(6+)照射的效果更为明显。
