Yaghini Jaber, Abed Ahmad Moghareh, Mostafavi Seyed Abolfazl, Roshanzamir Najmeh
Assistant Professor of Periodontology, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran.
Dent Res J (Isfahan). 2011 Summer;8(3):146-9.
The need to relieve pain and inflammation after periodontal surgery and the side effects of systemic drugs and advantages of topical drugs, made us to evaluate the effect of Diclofenac mouthwash on periodontal postoperative pain.
In this double-blind, randomized clinical trial study 20 quadrants of 10 patients(n = 20) aged between 22-54 who also acted as their own controls, were treated using Modified Widman Flap procedure in two quadrants of the same jaw with one month interval between the operations. After the operation in addition to ibuprofen 400 mg, one quadrant randomly received Diclofenac mouthwash (0/01%) for 30 seconds, 4 times a day (for a week) and for the contrary quadrant, ibuprofen and placebo mouthwash was given to be used in the same manner. The patients scored the number of ibuprofen consumption and their pain intensity based on VAS index in a questionnaire in days 1, 2, 3 and the first week after operation. The findings were analysed using two-way ANOVA, t-test and Wilcoxon. P-value less than 0.05 considered to be significant.
There was a significant difference between the mean values of pain intensity of two quadrants in four periods (P = 0.031). But, there was no significant difference between the average ibuprofen consumption in two groups (P = 0.51). Postoperative satisfaction was not significantly different in two quadrants (P = 0.059). 60% of patients preferred Diclofenac mouthwash.
Diclofenac mouthwash was effective in reducing postoperative periodontal pain but it seems that it isn't enough to control postoperative pain on its own.
牙周手术后缓解疼痛和炎症的需求，以及全身用药的副作用和局部用药的优势，促使我们评估双氯芬酸漱口水对牙周术后疼痛的影响。
在这项双盲、随机临床试验研究中，10名年龄在22至54岁之间的患者（n = 20）的20个象限，这些患者同时作为自身对照，在同一颌骨的两个象限采用改良Widman翻瓣术进行治疗，手术间隔为一个月。术后，除了服用400毫克布洛芬外，一个象限随机接受双氯芬酸漱口水（0.01%）30秒，每天4次（持续一周），而相对的象限则给予布洛芬和安慰剂漱口水，以相同方式使用。患者在术后第1、2、3天和第一周通过问卷根据视觉模拟评分（VAS）指数对布洛芬的服用次数和疼痛强度进行评分。使用双向方差分析、t检验和Wilcoxon检验对结果进行分析。P值小于0.05被认为具有统计学意义。
在四个时间段内，两个象限的疼痛强度平均值之间存在显著差异（P = 0.031）。但是，两组之间的布洛芬平均消耗量没有显著差异（P = 0.51）。两个象限的术后满意度没有显著差异（P = 0.059）。60%的患者更喜欢双氯芬酸漱口水。
双氯芬酸漱口水在减轻牙周术后疼痛方面有效，但似乎仅靠它不足以控制术后疼痛。
