乌干达抗逆转录病毒治疗前时代人类免疫缺陷病毒对孕产妇发病率的影响。
The impact of HIV on maternal morbidity in the Pre-HAART era in Uganda.
作者信息
Nuwagaba-Biribonwoha Harriet, Mayon-White Richard T, Okong Pius, Brocklehurst Peter, Carpenter Lucy M
机构信息
ICAP, Mailman School of Public Health, Columbia University, P.O. Box 3567, Kampala, Uganda.
出版信息
J Pregnancy. 2012;2012:508657. doi: 10.1155/2012/508657. Epub 2011 Oct 12.
OBJECTIVE
To compare maternal morbidity in HIV-infected and uninfected pregnant women.
METHODS
Major maternal morbidity (severe febrile illness, illnesses requiring hospital admissions, surgical revisions, or illnesses resulting in death) was measured prospectively in a cohort of HIV-infected and uninfected women followed from 36 weeks of pregnancy to 6 weeks after delivery. Odds ratios of major morbidity and associated factors were examined using logistic regression.
RESULTS
Major morbidity was observed in 46/129 (36%) and 104/390 (27%) of the HIV-infected and HIV-uninfected women, respectively, who remained in followup. In the multivariable analysis, major morbidity was independently associated with HIV infection, adjusted odds ratio (AOR) 1.7 (1.1 to 2.7), nulliparity (AOR 2.0 (1.3 to 3.0)), and lack of, or minimal, formal education (AOR 2.1 (1.1 to 3.8)).
CONCLUSIONS
HIV was associated with a 70% increase in the odds of major maternal morbidity in these Ugandan mothers.
目的
比较感染HIV和未感染HIV的孕妇的孕产妇发病率。
方法
对一组从妊娠36周直至产后6周进行随访的感染HIV和未感染HIV的女性前瞻性地测量主要孕产妇发病率（严重发热性疾病、需要住院治疗、手术修正或导致死亡的疾病）。使用逻辑回归分析主要发病率及相关因素的比值比。
结果
在仍处于随访中的感染HIV和未感染HIV的女性中，分别有46/129（36%）和104/390（27%）出现主要发病情况。在多变量分析中，主要发病情况与HIV感染独立相关，校正比值比（AOR）为1.7（1.1至2.7），与未生育（AOR 2.0（1.3至3.0））以及缺乏正规教育或接受极少正规教育（AOR 2.1（1.1至3.8））相关。
结论
在这些乌干达母亲中，HIV与孕产妇主要发病几率增加70%相关。
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