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[II型糖尿病合并糖尿病足综合征患者免疫紊乱的纠正]

[Correction of the immune disorders in patients with diabetes mellitus type II with complicated diabetic foot syndrome].

作者信息

Savon I L

出版信息

Klin Khir. 2011 Aug(8):55-8.

Abstract

There were examined 86 patients, suffering mixed form of diabetic foot syndrome. In all the patients diabetes mellitus type II was diagnosed, the disease duration have constituted (12.3 +/- 2.5) yrs at average. The immune status was estimated, using determination of the lymphocytes subpopulations with the help of the monoclonal antibodies towards antigens reaction by the flowcytometry method, as well as concentration of the main classes of immunoglobulins IgA, IgM, IgG. The investigation was performed in dynamics: immediately after a patient admittance to hospital, on the 7 - 8th, 12 - 16th and 25 - 30th day. Basing on the analysis of the data obtained, there was conclusion made, that immediately after admittance to the hospital in the patients, suffering complicated diabetic foot syndrome, the disorders of cellular immunity of degree II and of humoral immunity of I degree were revealed. The indices improvement were noted while application of certain immunocorrecting therapy.

摘要

对86例患有混合型糖尿病足综合征的患者进行了检查。所有患者均被诊断为II型糖尿病,疾病持续时间平均为(12.3±2.5)年。借助流式细胞术通过针对抗原反应的单克隆抗体测定淋巴细胞亚群以及主要免疫球蛋白类IgA、IgM、IgG的浓度来评估免疫状态。研究在动态过程中进行:患者入院后立即进行,以及在第7 - 8天、12 - 16天和25 - 30天进行。基于所获得数据的分析得出结论,患有复杂糖尿病足综合征的患者入院后立即出现了II度细胞免疫紊乱和I度体液免疫紊乱。在应用某些免疫纠正疗法时,指标有所改善。

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