Mu Yong-ping, Chen Xiao-rong, Zhang Ai-jun
Shanghai Public Health Clinical Center, Shanghai 201508.
Zhongguo Zhong Xi Yi Jie He Za Zhi. 2011 Sep;31(9):1209-12.
To study the clinical effects of Reduning Injection on ordinary hand, foot and mouth disease (HFMD) in children.
76 children with confirmed diagnosis of HFMD were randomly assigned to 3 groups by the center randomization method, i.e., the Western medicine group (WM, 24 cases, treated with Ribavirin Injection or antibiotics), the Reduning Injection group (RI, 26 cases, treated with Reduning Injection), and the combination group (26 cases, treated with the combination of Reduning injection with Ribavirin Injection or antibiotics). The therapeutic course lasted for 3 to 7 days. A 3-day follow-up study was performed by the end of the treatment. The blood routines, the liver function, the renal function, the fasting blood glucose, the pyretolysis effect initiating time, the time for the body temperature recovery, and the rash subside time were observed in the three groups.
(1) Of 76 patients, 13 dropped out, with the final effective case being 63. Of them, there were 19 cases in the WM group, 22 in the RI group, and 22 in the combination group. (2) Compared with the WM group, the pyretolysis effect initiating time and the time for the body temperature recovery were both significantly shortened in the RI group and the combination group (P<0.05, P<0.01). (3) There was no significant difference in the rash subside time among the three groups (P>0.05). But there was shortening tendency in the RI group and the combination group. (4) One child in the RI group dropped out from this study due to a mild rash, and no adverse drug reaction occurred in the other two groups.
RI had some advantages in treatment of HFMD such as fasting pyretolysis effect initiating time, shorter time for the body temperature recovery, higher safety. Besides, it also could accelerate the subside of skin rashes to some extent.
探讨热毒宁注射液治疗小儿普通型手足口病（HFMD）的临床疗效。
采用中心随机化方法，将76例确诊为手足口病的患儿随机分为3组，即西药组（24例，采用利巴韦林注射液或抗生素治疗）、热毒宁注射液组（26例，采用热毒宁注射液治疗）、联合组（26例，采用热毒宁注射液联合利巴韦林注射液或抗生素治疗）。疗程为3至7天。治疗结束后进行3天随访。观察三组患儿的血常规、肝功能、肾功能、空腹血糖、退热起效时间、体温恢复时间及皮疹消退时间。
（1）76例患者中，13例脱落，最终有效病例为63例。其中西药组19例，热毒宁注射液组22例，联合组22例。（2）与西药组比较，热毒宁注射液组和联合组的退热起效时间及体温恢复时间均明显缩短（P<0.05，P<0.01）。（3）三组皮疹消退时间比较，差异无统计学意义（P>0.05），但热毒宁注射液组和联合组有缩短趋势。（4）热毒宁注射液组有1例患儿因轻度皮疹退出本研究，其他两组未发生药物不良反应。
热毒宁注射液治疗手足口病具有退热起效快、体温恢复时间短、安全性高的优点，且在一定程度上可加速皮疹消退。
