Department of Histopathology, Bristol Royal Infirmary Department of Cellular Pathology, Southmead Hospital, UK.
Histopathology. 2011 Oct;59(4):781-5. doi: 10.1111/j.1365-2559.2011.03979.x.
Gastrointestinal stromal tumour (GIST) may share morphological and/or immunohistochemical features with various intra-abdominal neoplasms, including endometrial stromal sarcoma, perivascular epithelioid cell tumour (PEComa), melanoma and synovial sarcoma. Each of these various neoplasms has characteristic immunohistochemical markers, including epithelial membrane antigen (EMA), CD10, oestrogen receptor alpha (ERa) and/or HMB45, and therefore the primary aim of this study was to determine whether these markers are also expressed by GISTs.
Standard size sections of 52 GISTs were immunostained for EMA, CD10, ERa and a melanoma marker cocktail (targeting HMB45 and melan-A). Ten GISTs (19%) showed CD10 immunopositivity. This positivity was confined almost completely to small intestinal GISTs, and was seen among spindle cell GISTs but not epithelioid or mixed cell-type GISTs. Five of the 52 GISTs (9.6%) showed EMA immunopositivity. This positivity was always focal and usually seen in a perivascular location. None of the GISTs showed immunopositivity for ERa or the melanoma marker cocktail.
GISTs occasionally show CD10 immunopositivity (especially small intestinal spindle cell GISTs), and infrequently show focal EMA positivity. GISTs do not show immunopositivity for ERa or HMB45.
胃肠道间质瘤（GIST）可能与各种腹腔内肿瘤具有形态学和/或免疫组织化学特征，包括子宫内膜间质肉瘤、血管周上皮样细胞瘤（PEComa）、黑色素瘤和滑膜肉瘤。这些不同的肿瘤中的每一种都具有特征性的免疫组织化学标志物，包括上皮膜抗原（EMA）、CD10、雌激素受体α（ERa）和/或 HMB45，因此本研究的主要目的是确定这些标志物是否也存在于 GIST 中。
对 52 例 GIST 的标准大小切片进行 EMA、CD10、ERa 和黑色素瘤标志物鸡尾酒（针对 HMB45 和黑色素瘤-A）的免疫染色。10 例 GIST（19%）显示 CD10 免疫阳性。这种阳性几乎完全局限于小肠 GIST，并且在梭形细胞 GIST 中可见，但不在上皮样或混合细胞类型 GIST 中可见。52 例 GIST 中有 5 例（9.6%）显示 EMA 免疫阳性。这种阳性通常是局灶性的，通常位于血管周围位置。没有 GIST 显示 ERa 或黑色素瘤标志物鸡尾酒的免疫阳性。
GIST 偶尔显示 CD10 免疫阳性（尤其是小肠梭形细胞 GIST），并且很少显示局灶性 EMA 阳性。GIST 对 ERa 或 HMB45 无免疫阳性。
