Rico A
Laboratoire de toxicologie biochimique et métabolique (I.N.R.A.), Toulouse.
Bull Acad Natl Med. 1990 Mar;174(3):365-9; discussion 369-70.
Two types of metabolites can be expected in food prepared from animals or plants treated with veterinary drugs or pesticides. The first types are represented by the drug itself and/or its primary metabolites as free or conjugated forms. Except for highly lipophilic compounds, these metabolites generally appear early and are noncumulative, since they are metabolized and eliminated rapidly. These substances may have toxic properties and may be metabolized to highly reactive electrophilic intermediates. We consider that they may be potentially toxic for consumers. The second type include covalently bound metabolites which appear later. Their presence can indicate a potential toxic effect in the target species, although these compounds have lost their chemical reactivity. They therefore probably represent low toxicity for consumers, especially considering their low bioavailability, which has been demonstrated for many veterinary drugs and pesticides.
在用兽药或农药处理过的动植物制成的食品中，可能会出现两种类型的代谢物。第一种类型以药物本身和/或其游离或结合形式的主要代谢物为代表。除了高度亲脂性化合物外，这些代谢物通常出现较早且不会累积，因为它们会迅速代谢并消除。这些物质可能具有毒性，并且可能代谢为高反应性亲电中间体。我们认为它们可能对消费者具有潜在毒性。第二种类型包括后期出现的共价结合代谢物。它们的存在可能表明对目标物种有潜在的毒性作用，尽管这些化合物已失去化学反应性。因此，考虑到它们的低生物利用度（许多兽药和农药已证明了这一点），它们可能对消费者的毒性较低。
