细胞周期之外的细胞周期蛋白：突触的新伙伴。

Cyclin beyond the cell cycle: new partners at the synapse.

机构信息

Indian Institute for Science Education and Research, Pashan Road, Pune 411021, Maharashtra, India.

出版信息

Dev Cell. 2011 Oct 18;21(4):601-2. doi: 10.1016/j.devcel.2011.09.015.

DOI:10.1016/j.devcel.2011.09.015

PMID:22014516

Abstract

In this issue of Developmental Cell, Odajima, Wills, and colleagues (2011) demonstrate that the cell-cycle regulator, cyclin E, sequesters Cdk5, a key regulator of neuronal development and synaptic plasticity. This cell-cycle-independent function of cyclin E reveals an exciting mode of Cdk5 regulation in postmitotic neurons and offers a window into evolutionary parsimony.

摘要

在本期《发育细胞》中，Odajima、Wills 及其同事（2011）证明了细胞周期调控因子 cyclin E 可将 Cdk5 隔离，后者是神经元发育和突触可塑性的关键调控因子。cyclin E 的这种与细胞周期无关的功能揭示了 CDK5 在有丝分裂后神经元中的一种令人兴奋的调控模式，并为进化简约性提供了一个窗口。