2-取代腺嘌呤作为小沟修饰剂稳定 DNA 双链。
Stabilization of DNA duplex by 2-substituted adenine as a minor groove modifier.
机构信息
Department of Chemical Biology and Applied Chemistry, School of Engineering, Nihon University, Koriyama, Fukushima, Japan.
出版信息
Bioorg Med Chem Lett. 2011 Dec 1;21(23):7021-4. doi: 10.1016/j.bmcl.2011.09.104. Epub 2011 Oct 1.
2-(1-Naphthalenylethynyl)-2'-deoxyadenosine ((N)A) was synthesized and incorporated into oligodeoxynucleotides. DNA duplexes containing newly designed 5'-(N)AT-3'/3'-T(N)A-5' base pairs are considerably stabilized than unmodified duplexes by stacking interaction of naphthalene rings in the narrow minor groove as characterized by a new emission at longer wavelength and exciton coupled CD signals.
2-(1-萘基乙炔基)-2'-脱氧腺苷((N)A)被合成并掺入寡脱氧核苷酸中。含有新设计的 5'-(N)AT-3'/3'-T(N)A-5'碱基对的 DNA 双链体通过萘环在狭窄的小沟中的堆积相互作用而得到相当程度的稳定，这表现在更长波长处的新发射和激子耦合 CD 信号上。
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