Department of Developmental Biology, Howard Hughes Medical Institute, Lorry I. Lokey Stem Cell Research Building, Stanford University, School of Medicine, Stanford, CA 94305-5458, USA.
Cancer Cell. 2011 Oct 18;20(4):415-6. doi: 10.1016/j.ccr.2011.10.003.
Genetic alterations in the Wnt/β-catenin/TCF-signaling pathway are commonly found in human tumors, but not in glioblastomas. In this issue of Cancer Cell, Zhang et al. report that FoxM1 mediates β-catenin nuclear translocation in glioblastoma, suggesting a novel mechanism for glioblastoma progression in the absence of conventional Wnt/β-catenin pathway activation.
Wnt/β-catenin/TCF 信号通路中的遗传改变在人类肿瘤中很常见，但在神经胶质瘤中却不存在。在本期《癌细胞》杂志中，Zhang 等人报道 FoxM1 介导了神经胶质瘤中 β-catenin 的核易位，提示在没有传统 Wnt/β-catenin 通路激活的情况下，神经胶质瘤进展存在新的机制。
