Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Cancer Cell. 2011 Oct 18;20(4):416-8. doi: 10.1016/j.ccr.2011.10.002.
Oncolytic viruses exploit molecular differences between normal and cancer cells to selectively kill the latter. Results of a synthetic lethal screen described in this issue of Cancer Cell demonstrate that components of the unfolded protein response (UPR) limit virus-induced tumor cell killing and identify a strategy to utilize this knowledge.
溶瘤病毒利用正常细胞和癌细胞之间的分子差异，有选择性地杀死后者。本期《癌细胞》杂志中描述的一个合成致死筛选的结果表明，未折叠蛋白反应（UPR）的组成部分限制了病毒诱导的肿瘤细胞杀伤，并确定了利用这一知识的策略。
