UPMC Univ Paris 06 Er 6, Physiologie et physiopathologie de la motricité chez l'Homme, Médecine Physique et Réadaptation, Hôpital Pitié Salpêtrière, 75013 Paris, France.
Clin Neurophysiol. 2012 May;123(5):1027-34. doi: 10.1016/j.clinph.2011.09.011. Epub 2011 Oct 20.
It has recently been shown that transcranial direct current stimulation (tDCS) (1) can modify lumbar spinal network excitability and (2) decreases cervical propriospinal system excitability. Thus the purpose of this series of experiments was to determine if anodal tDCS applied over the leg motor cortex area induces changes in lumbar propriospinal system excitability. To that end, the effects of anodal tDCS and sham tDCS on group I and group II propriospinal facilitation of quadriceps motoneurones were studied in healthy subjects.
Common peroneal nerve group I and group II quadriceps H-reflex facilitation was assessed in 15 healthy subjects in two randomised conditions: anodal tDCS condition and sham tDCS condition. Recordings were performed before, during and after the end of the cortical stimulation.
Compared to sham, anodal tDCS decreases significantly CPN-induced group I and II quadriceps H-reflex facilitation during and also after the end of the cortical stimulation.
Anodal tDCS induces (1) modulation of lumbar propriospinal system excitability (2) post-effects on spinal network.
These results open a new vista to regulate propriospinal lumbar system excitability in patients and suggest that anodal tDCS would be interesting for neuro-rehabilitation of patients with central nervous system lesions.
最近有研究表明，经颅直流电刺激（tDCS）（1）可以改变腰椎脊柱网络的兴奋性，（2）降低颈段固有脊髓系统的兴奋性。因此，本系列实验的目的是确定在腿部运动皮质区施加阳极 tDCS 是否会引起腰椎固有脊髓系统兴奋性的变化。为此，我们研究了阳极 tDCS 和假 tDCS 对健康受试者股四头肌运动神经元的 I 组和 II 组固有脊髓易化的影响。
在 15 名健康受试者中，在两种随机条件下评估腓总神经 I 组和 II 组股四头肌 H 反射易化：阳极 tDCS 条件和假 tDCS 条件。在皮质刺激之前、期间和结束后进行记录。
与假 tDCS 相比，阳极 tDCS 在皮质刺激期间和结束后显著降低了 CPN 诱导的 I 组和 II 组股四头肌 H 反射易化。
阳极 tDCS 诱导（1）腰椎固有脊髓系统兴奋性的调节（2）对脊髓网络的后效。
这些结果为调节患者腰椎固有脊髓系统兴奋性开辟了新的前景，并表明阳极 tDCS 对中枢神经系统损伤患者的神经康复具有重要意义。
