University of Arizona, Department of Internal Medicine, Tucson, AZ 85724, USA.
Med Hypotheses. 2012 Jan;78(1):29-32. doi: 10.1016/j.mehy.2011.09.034. Epub 2011 Oct 19.
Obesity is a growing epidemic in the United States (US). Obesity has been recognized as a modifiable risk factor for many diverse diseases including diabetes, cardiovascular disease and cancer burden. Common contributors to obesity include a high fat diet, smoking and physical inactivity. Systemic effects of obesity include increased micro-inflammatory molecules such as nuclear factor kappa B (NF-κB) that influence the both endothelial and epithelial layers as well as the supportive stroma. An emerging risk factor for micro-inflammation also includes periodontal disease. These pro-inflammatory states are hypothesized to contribute to diabetes as well as cardiovascular disease and cancer through the direct activation of NF-κB. Therefore, a comprehensive health care strategy would include reduction of diabetes, cardiovascular and cancer risk through the decrease in micro-inflammation.
肥胖是美国日益严重的流行病。肥胖已被认为是多种疾病的可改变风险因素，包括糖尿病、心血管疾病和癌症负担。肥胖的常见促成因素包括高脂肪饮食、吸烟和缺乏身体活动。肥胖的全身影响包括增加核因子 kappa B（NF-κB）等微小炎症分子，这些分子会影响内皮细胞和上皮细胞以及支持性基质。牙周病也是一种新出现的微炎症危险因素。这些促炎状态被假设通过 NF-κB 的直接激活，导致糖尿病以及心血管疾病和癌症的发生。因此，综合保健策略将包括通过减少微炎症来降低糖尿病、心血管疾病和癌症的风险。
