Department of Urology, Faculty of Medicine, Assiut University, Assiut, Egypt.
Urology. 2011 Dec;78(6):1351-4. doi: 10.1016/j.urology.2011.06.054. Epub 2011 Oct 19.
To determine possible risk factors associated with prostate invasion in patients with squamous cell carcinoma (SCC) of the urinary bladder associated with bilharziasis.
After obtaining approval from the medical ethics committee, we reviewed the clinical and pathologic data from 236 male patients in our department between January 2006 and October 2010 who were treated with radical cystoprostatectomy and proved to have SCC associated with bilharziasis. We reviewed the clinical and histopathologic data regarding prostate infiltration from SCC of the urinary bladder associated with bilharziasis.
Two-hundred thirty-six patients were included in this study. Prostate infiltration was present in 14 patients (5.9%). Tumor located in the bladder neck (P = .000001), tumors >5 cm (P = .009), and advanced clinical tumor stage (P = .000001) were associated with highly statistically significant increased risk of prostate invasion from SCC of the urinary bladder. Different patients' ages, high tumor grade, and regional lymph nodes' metastasis were not associated with increased risk of prostate invasion from SCC of the urinary bladder.
Prostate infiltration from SCC of the urinary bladder (which is associated with bilharziasis) is not uncommon. Tumor >5 cm, bladder neck tumor, and high clinical tumor stages should be considered at least relative contraindications for prostate-sparing cystectomy.
确定与埃及血吸虫病相关的膀胱癌鳞状细胞癌（SCC）患者前列腺浸润的可能相关危险因素。
在获得医学伦理委员会批准后，我们回顾了 2006 年 1 月至 2010 年 10 月期间在我院接受根治性膀胱切除术治疗且证实患有埃及血吸虫病相关 SCC 的 236 例男性患者的临床和病理数据。我们回顾了与埃及血吸虫病相关的膀胱癌 SCC 中前列腺浸润的临床和组织病理学数据。
本研究共纳入 236 例患者。14 例（5.9%）患者存在前列腺浸润。肿瘤位于膀胱颈部（P=0.000001）、肿瘤>5cm（P=0.009）和临床肿瘤晚期（P=0.000001）与膀胱癌 SCC 前列腺浸润的风险显著增加相关。不同患者的年龄、高肿瘤分级和区域淋巴结转移与膀胱癌 SCC 前列腺浸润的风险增加无关。
与埃及血吸虫病相关的膀胱癌（伴 SCC）的前列腺浸润并不少见。肿瘤>5cm、膀胱颈部肿瘤和高临床肿瘤分期应被视为至少保留前列腺的膀胱切除术的相对禁忌症。
