Department of Pediatrics, Jikei University Daisan Hospital, Komae City, Tokyo, Japan.
Allergol Int. 2012 Mar;61(1):75-82. doi: 10.2332/allergolint.11-OA-0306. Epub 2011 Oct 25.
The pandemic influenza A (H1N1) 2009 [pdm (H1N1) 2009] spread through the world in 2009, producing a serious epidemic in Japan. Since it was suggested early that asthma is a risk factor for an increased severity of the infection, the Japanese Society of Pediatric Allergy and Clinical Immunology (JSPACI) organized a working group for countermeasures, and investigated asthmatic children admitted to the hospitals for pdm (H1N1) 2009 infection.
An appeal was made on the home page of the JSPACI to medical practitioners to input clinical information about asthmatic and non-asthmatic children (0-19 years) admitted to the hospital with pdm (H1N1) 2009 infection.
A total of 862 children (390 with asthma, and 472 without asthma) from 61 medical centers were registered, and the data of 333 asthmatic children and 388 non-asthmatic children in all were entered in the analyses. The mean age was 7.4 ± 2.9 years in the asthma group and 6.9 ± 3.8 years in the non-asthma group. The percentage of children admitted for respiratory symptoms was significantly higher in the asthma group than in the non-asthma group (p < 0.001). There was no significant difference in the frequency of admission to the ICU or need for mechanical ventilation support between the two groups. No definite trend was detected in the relationship between the severity of asthma and the intensity of asthma attack. Antiviral drugs were administered within 24 hours in about 85% of the patients in both groups.
Asthma may not be a risk factor for severe pdm (H1N1) 2009 infection in children.
2009 年甲型流感（H1N1）[季节性 H1N1（H1N1pdm）2009]在全球范围内传播，在日本引发了严重疫情。由于早期有研究提示哮喘是感染加重的危险因素，日本小儿过敏和临床免疫学会（JSPACI）组织了一个工作组来制定对策，并对因季节性 H1N1（H1N1pdm）2009 感染而住院的哮喘患儿进行了调查。
JSPACI 在其主页上向医务人员发出呼吁，要求输入因季节性 H1N1（H1N1pdm）2009 感染而住院的哮喘和非哮喘患儿（0-19 岁）的临床信息。
共登记了来自 61 家医疗中心的 862 名儿童（390 名哮喘患儿，472 名非哮喘患儿），对所有 333 名哮喘患儿和 388 名非哮喘患儿的数据进行了分析。哮喘组的平均年龄为 7.4±2.9 岁，非哮喘组为 6.9±3.8 岁。哮喘组因呼吸系统症状入院的患儿比例显著高于非哮喘组（p＜0.001）。两组患儿入住 ICU 或需要机械通气支持的频率无显著差异。哮喘严重程度与哮喘发作严重程度之间未发现明确的关系趋势。两组患儿抗病毒药物的给药时间均在 24 小时内。
哮喘可能不是儿童严重季节性 H1N1（H1N1pdm）2009 感染的危险因素。
