Center for Chemoprevention and Cancer Drug Development, Department of Medicine, Medical Oncology, PC Stephenson Oklahoma Cancer Center, University of Oklahoma Health Sciences Center, 975 NE 10th Street, BRC 1203, Oklahoma City, OK 73104, USA.
Cancer Metastasis Rev. 2011 Dec;30(3-4):507-23. doi: 10.1007/s10555-011-9311-2.
Unresolved inflammation, due to insufficient production of proresolving anti-inflammatory lipid mediators, can lead to an increased risk of tumorigenesis and tumor cell invasiveness. Various bioactive lipids, particularly those formed by cyclooxygenase (COX) and lipoxygenase (LOX) enzymes, have been well established as therapeutic targets for many epithelial cancers. Emerging studies suggest that there is a role for anti-inflammatory bioactive lipids and their mediators during the resolution phase of inflammation. These proresolving bioactive lipids, including lipoxins (LXs) and resolvins (RVs), have potent anti-inflammatory and anti-carcinogenic properties. The molecular signaling pathways controlling generation and degradation of the proresolving mediators LXs and RVs are now being elucidated, and the component molecules may serve as new targets for regulation of inflammation and inflammation-associated cancers like colon and pancreatic cancers. This review will highlight the recent advances in our understanding of how these bioactive lipids and proresolving mediators may function with various immune cells and cytokines in inhibiting tumor cell proliferation and progression and invasiveness of colon and pancreatic cancers.
未解决的炎症，由于促炎抗炎脂质介质的产生不足，可能会增加肿瘤发生和肿瘤细胞侵袭的风险。各种生物活性脂质，特别是由环氧化酶 (COX) 和脂氧合酶 (LOX) 酶形成的脂质，已被确立为许多上皮癌的治疗靶点。新出现的研究表明，在炎症的消退阶段，抗炎生物活性脂质及其介质发挥作用。这些促炎消退的生物活性脂质，包括脂氧素 (LX) 和消退素 (RV)，具有强大的抗炎和抗癌特性。控制促炎消退介质 LX 和 RV 产生和降解的分子信号通路正在被阐明，组成分子可能作为调节炎症和炎症相关癌症（如结肠癌和胰腺癌）的新靶点。这篇综述将重点介绍我们对这些生物活性脂质和促炎消退介质如何与各种免疫细胞和细胞因子相互作用，从而抑制结肠癌和胰腺癌中肿瘤细胞增殖、进展和侵袭的理解的最新进展。
