Department of Neurosurgery, The First Affiliated Hospital of Chongqing Medical University, PR China.
Neurosci Lett. 2011 Nov 14;505(2):160-4. doi: 10.1016/j.neulet.2011.10.011. Epub 2011 Oct 12.
Although several studies have revealed the EEG alterations in AD and TBI patients, the influence of APOE (apolipoprotein E) genotype in EEG at the early stage of TBI has not been reported yet. We have previously studied EEG alterations caused by TBI among different APOE genotype carriers. In this study, we firstly investigated the relationship between APOE polymorphisms and quantitative EEG (QEEG) changes after TBI. A total of 118 consecutive TBI patients with a Glasgow Coma Scale (GCS) of 9 or higher were recruited, and 40 normal adults were also included as a control group. APOE genotype was determined by PCR-RFLP for each subject, and QEEG recordings were performed in rest, relaxed, awake and with eyes closed in normal subjects and TBI patients during 1-3 days after TBI. In the normal control group, both APOEɛ4 carriers and non-carriers had normal EEG, and no significant difference of QEEG data was found between APOEɛ4 carriers and non-carriers. But in the TBI group, APOEɛ4 carriers had more focal or global irregular slow wave activities than APOEɛ4 non-carriers. APOE gene did not influence brain electrical activity under normal conditions, but TBI can induce different alterations among different APOE gene carriers, and APOEɛ4 allele enhances the EEG abnormalities at the early stage of TBI.
尽管已有多项研究揭示了 AD 和 TBI 患者的 EEG 改变，但 APOE（载脂蛋白 E）基因型对 TBI 早期 EEG 的影响尚未见报道。我们之前曾研究过不同 APOE 基因型携带者的 TBI 引起的 EEG 改变。在这项研究中，我们首先研究了 APOE 多态性与 TBI 后定量 EEG（QEEG）变化之间的关系。共纳入 118 例格拉斯哥昏迷量表（GCS）评分≥9 分的连续 TBI 患者，同时纳入 40 例正常成年人作为对照组。采用 PCR-RFLP 法确定每位受试者的 APOE 基因型，在正常受试者和 TBI 患者伤后 1-3 天，分别在静息、放松、清醒和闭眼状态下进行 QEEG 记录。在正常对照组中，APOEɛ4 携带者和非携带者的 EEG 均正常，APOEɛ4 携带者和非携带者的 QEEG 数据无显著差异。但在 TBI 组中，APOEɛ4 携带者的局灶性或全脑不规则慢波活动较 APOEɛ4 非携带者多。APOE 基因在正常情况下不影响脑电活动，但 TBI 可在不同 APOE 基因携带者中引起不同的改变，APOEɛ4 等位基因增强了 TBI 早期的 EEG 异常。
