From Maternal Fetal Medicine Associates, PLLC, and the Department of Obstetrics, Gynecology, and Reproductive Science, Mount Sinai School of Medicine, New York, New York.
Obstet Gynecol. 2011 Nov;118(5):1000-1004. doi: 10.1097/AOG.0b013e318232125d.
To estimate pregnancy outcomes in twin pregnancies with excessive weight gain, according to the 2009 Institute of Medicine (IOM) recommendations.
A retrospective cohort of 170 patients from a single practice with twin pregnancies at 37 weeks or more of gestation from 2005 to 2010 were analyzed. We compared outcomes between three cohorts based on the 2009 IOM recommendations for weight gain during pregnancy: poor weight gain, normal weight gain, and excessive weight gain. One-way analysis of variance and χ for trend were used when appropriate.
Comparing poor, normal, and excessive weight gain, the proportion of women delivering both newborns weighing more than 2,500 g increased from 40% to 60.5% to 79.5% across the three groups (P<.001). Additionally, the mean birth weight of the larger (P<.001) and smaller (P=.002) twin increased significantly across the three groups. The proportion of women with gestational diabetes, gestational hypertension, or pre-eclampsia did not increase significantly across the three subgroups. Our results were similar when we only included women with a normal prepregnancy body mass index.
Excessive weight gain in term twin gestations, as defined by the IOM, does not appear to be associated with worse maternal outcomes and is associated with larger birth weights. Our results call into question the 2009 IOM definition of excessive weight gain for a twin pregnancy.
根据 2009 年美国医学研究所(IOM)的建议,评估体重过度增加的双胎妊娠的妊娠结局。
对 2005 年至 2010 年在一家诊所就诊的 170 例妊娠 37 周及以上的双胎妊娠患者进行回顾性队列研究。我们根据 2009 年 IOM 关于妊娠期间体重增加的建议,将患者分为三组,比较三组之间的结局:体重增加不足、正常体重增加和体重过度增加。当合适时,采用单因素方差分析和 χ²检验进行比较。
比较体重增加不足、正常和过度的三组患者,分娩两个新生儿体重均超过 2500 克的比例从 40%增加到 60.5%,再增加到 79.5%(P<.001)。此外,两个新生儿中较大的(P<.001)和较小的(P=.002)的出生体重也随三组的变化而显著增加。三组患者中妊娠期糖尿病、妊娠期高血压或先兆子痫的比例无显著增加。当我们仅纳入孕前 BMI 正常的患者时,我们的结果也相似。
根据 IOM 的定义,足月双胎妊娠中体重过度增加似乎与不良的母婴结局无关,反而与更大的出生体重相关。我们的结果对 2009 年 IOM 对双胎妊娠体重过度增加的定义提出了质疑。