这是一把双刃剑：caspase 8 在细胞死亡和存活中的双重角色需要调和。
It cuts both ways: reconciling the dual roles of caspase 8 in cell death and survival.
机构信息
Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
出版信息
Nat Rev Mol Cell Biol. 2011 Oct 21;12(11):757-63. doi: 10.1038/nrm3214.
Abstract
Caspase 8 can initiate apoptosis, but it also has non-apoptotic roles; for example, it is required for embryonic development and immune cell proliferation. Recent work has indicated that the requirement for caspase 8 in development and immune cell proliferation is defined by suppression of receptor-interacting protein kinase 3 (RIPK3), a kinase that triggers an alternative form of cell death called programmed necrosis. Interestingly, these recent findings can be reconciled with earlier work on the non-apoptotic roles of caspase 8.
摘要
半胱天冬酶 8 可以启动细胞凋亡，但它也具有非凋亡作用；例如，它是胚胎发育和免疫细胞增殖所必需的。最近的研究表明，caspase 8 在发育和免疫细胞增殖中的作用是通过抑制受体相互作用蛋白激酶 3（RIPK3）来定义的，RIPK3 是一种激酶，它触发一种称为程序性坏死的细胞死亡的另一种形式。有趣的是，这些最近的发现可以与 caspase 8 的非凋亡作用的早期研究相协调。
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本文引用的文献
1
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Nat Cell Biol. 2011 Oct 30;13(12):1437-42. doi: 10.1038/ncb2362.
2
Complementary roles of Fas-associated death domain (FADD) and receptor interacting protein kinase-3 (RIPK3) in T-cell homeostasis and antiviral immunity.Fas 相关死亡结构域（FADD）和受体相互作用蛋白激酶-3（RIPK3）在 T 细胞动态平衡和抗病毒免疫中的互补作用。
Proc Natl Acad Sci U S A. 2011 Sep 13;108(37):15312-7. doi: 10.1073/pnas.1102779108. Epub 2011 Aug 29.
3
FADD prevents RIP3-mediated epithelial cell necrosis and chronic intestinal inflammation.FADD 可防止 RIP3 介导的上皮细胞坏死和慢性肠道炎症。
Nature. 2011 Jul 31;477(7364):330-4. doi: 10.1038/nature10273.
4
cIAPs block Ripoptosome formation, a RIP1/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoforms.cIAPs 阻止 Ripoptosome 的形成，Ripoptosome 是一种包含 RIP1/caspase-8 的细胞内死亡复合物，其受到不同 cFLIP 同工型的调控。
Mol Cell. 2011 Aug 5;43(3):449-63. doi: 10.1016/j.molcel.2011.06.011. Epub 2011 Jul 7.
5
The Ripoptosome, a signaling platform that assembles in response to genotoxic stress and loss of IAPs.Ripoptosome，一种信号平台，在应对基因毒性应激和 IAPs 缺失时组装。
Mol Cell. 2011 Aug 5;43(3):432-48. doi: 10.1016/j.molcel.2011.06.006. Epub 2011 Jul 7.
6
Linear ubiquitination prevents inflammation and regulates immune signalling.线性泛素化可预防炎症并调节免疫信号转导。
Nature. 2011 Mar 31;471(7340):591-6. doi: 10.1038/nature09816.
7
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Immunity. 2011 Mar 25;34(3):340-51. doi: 10.1016/j.immuni.2010.12.018.
8
Mechanisms of necroptosis in T cells.T 细胞坏死性凋亡的机制。
J Exp Med. 2011 Apr 11;208(4):633-41. doi: 10.1084/jem.20110251. Epub 2011 Mar 14.
9
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Nature. 2011 Mar 17;471(7338):363-7. doi: 10.1038/nature09852. Epub 2011 Mar 2.
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RIP3 mediates the embryonic lethality of caspase-8-deficient mice.RIP3 介导 caspase-8 缺陷型小鼠的胚胎致死性。
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