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It cuts both ways: reconciling the dual roles of caspase 8 in cell death and survival.
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Survival function of the FADD-CASPASE-8-cFLIP(L) complex.
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Death in the fast lane: what's next for necroptosis?
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Control of life-or-death decisions by RIP1 kinase.
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Cellular FLICE-like inhibitory protein secures intestinal epithelial cell survival and immune homeostasis by regulating caspase-8.
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Ripped to death.
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9
Differential signaling to apoptotic and necrotic cell death by Fas-associated death domain protein FADD.
J Biol Chem. 2004 Feb 27;279(9):7925-33. doi: 10.1074/jbc.M307807200. Epub 2003 Dec 10.
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RIPK1 prevents TRADD-driven, but TNFR1 independent, apoptosis during development.
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The Crosstalk of Apoptotic and Non-Apoptotic Signaling in CD95 System.
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Regulated cell death pathways and their roles in homeostasis, infection, inflammation, and tumorigenesis.
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TNF-α-Mediated Endothelial Cell Apoptosis Is Rescued by Hydrogen Sulfide.
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Targeting Neutrophils for Promoting the Resolution of Inflammation.
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The evolution of regulated cell death pathways in animals and their evasion by pathogens.
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TAK1: A Molecular Link Between Liver Inflammation, Fibrosis, Steatosis, and Carcinogenesis.
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Mixed lineage kinase domain-like pseudokinase-mediated necroptosis aggravates periodontitis progression.
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本文引用的文献

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Caspase 8 inhibits programmed necrosis by processing CYLD.
Nat Cell Biol. 2011 Oct 30;13(12):1437-42. doi: 10.1038/ncb2362.
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Complementary roles of Fas-associated death domain (FADD) and receptor interacting protein kinase-3 (RIPK3) in T-cell homeostasis and antiviral immunity.
Proc Natl Acad Sci U S A. 2011 Sep 13;108(37):15312-7. doi: 10.1073/pnas.1102779108. Epub 2011 Aug 29.
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FADD prevents RIP3-mediated epithelial cell necrosis and chronic intestinal inflammation.
Nature. 2011 Jul 31;477(7364):330-4. doi: 10.1038/nature10273.
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The Ripoptosome, a signaling platform that assembles in response to genotoxic stress and loss of IAPs.
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Linear ubiquitination prevents inflammation and regulates immune signalling.
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Mechanisms of necroptosis in T cells.
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Catalytic activity of the caspase-8-FLIP(L) complex inhibits RIPK3-dependent necrosis.
Nature. 2011 Mar 17;471(7338):363-7. doi: 10.1038/nature09852. Epub 2011 Mar 2.
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RIP3 mediates the embryonic lethality of caspase-8-deficient mice.
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