Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
Nat Rev Mol Cell Biol. 2011 Oct 21;12(11):757-63. doi: 10.1038/nrm3214.
Caspase 8 can initiate apoptosis, but it also has non-apoptotic roles; for example, it is required for embryonic development and immune cell proliferation. Recent work has indicated that the requirement for caspase 8 in development and immune cell proliferation is defined by suppression of receptor-interacting protein kinase 3 (RIPK3), a kinase that triggers an alternative form of cell death called programmed necrosis. Interestingly, these recent findings can be reconciled with earlier work on the non-apoptotic roles of caspase 8.
半胱天冬酶 8 可以启动细胞凋亡,但它也具有非凋亡作用;例如,它是胚胎发育和免疫细胞增殖所必需的。最近的研究表明,caspase 8 在发育和免疫细胞增殖中的作用是通过抑制受体相互作用蛋白激酶 3(RIPK3)来定义的,RIPK3 是一种激酶,它触发一种称为程序性坏死的细胞死亡的另一种形式。有趣的是,这些最近的发现可以与 caspase 8 的非凋亡作用的早期研究相协调。