Department of Molecular and Cellular Biology, University of California, Davis, California, USA.
Dev Dyn. 2011 Sep;240(9):2084-100. doi: 10.1002/dvdy.22715.
Migration and differentiation of cranial neural crest cells are largely controlled by environmental cues, whereas pathfinding at the trunk level is dictated by cell-autonomous molecular changes owing to early specification of the premigratory crest. Here, we investigated the migration and patterning of vagal neural crest cells. We show that (1) vagal neural crest cells exhibit some developmental bias, and (2) they take separate pathways to the heart and to the gut. Together these observations suggest that prior specification dictates initial pathway choice. However, when we challenged the vagal neural crest cells with different migratory environments, we observed that the behavior of the anterior vagal neural crest cells (somite-level 1-3) exhibit considerable migratory plasticity, whereas the posterior vagal neural crest cells (somite-level 5-7) are more restricted in their behavior. We conclude that the vagal neural crest is a transitional population that has evolved between the head and the trunk.
颅神经嵴细胞的迁移和分化在很大程度上受环境线索的控制，而躯干水平的轨迹形成则由早期迁移前嵴细胞的自主分子变化决定。在这里，我们研究了迷走神经嵴细胞的迁移和模式形成。我们表明：（1）迷走神经嵴细胞表现出一定的发育偏向；（2）它们通过不同的途径到达心脏和肠道。这些观察结果表明，预先指定决定了初始途径选择。然而，当我们用不同的迁移环境挑战迷走神经嵴细胞时，我们观察到前迷走神经嵴细胞（体节 1-3 水平）表现出相当大的迁移可塑性，而后迷走神经嵴细胞（体节 5-7 水平）的行为受到更多限制。我们得出结论，迷走神经嵴是一种在头部和躯干之间进化而来的过渡群体。
