The Stanley J. Dudrick Department of Surgery, Saint Mary’s Hospital, Waterbury, Connecticut, USA.
J Gerontol A Biol Sci Med Sci. 2012 Feb;67(2):109-17. doi: 10.1093/gerona/glr190. Epub 2011 Oct 19.
Carotid angioplasty is associated with adverse events in elderly patients; it is unclear whether this is related to an altered inflammatory axis. The carotid arteries of young (6 months) or aged (22-24 months) Fischer 344 rats were balloon injured. Aged rats had reduced lumen area (0.18 ± 0.03 vs 0.24 ± 0.01 mm(2), p = .02) and increased neointimal thickening (0.15 ± 0.04 vs 0.08 ± 0.03 mm(2), p = .006). Aged rats had increased circulating monocytes (96 ± 21 vs. 54 ± 7; p = .002) as well as increased numbers of monocytes at the post-angioplasty site. Aged rats had sustained monocyte chemotactic protein-1 expression after angioplasty but young rats did not. Aged arteries also exhibited defective vasorelaxation and abnormal eNOS localization. Aged (≥80 years) human patients with high-grade carotid stenosis had increased number of monocytes (9.1% ± 0.4%) compared with younger (65-80 years) patients (8.1% ± 0.3%, p = .013). Aged rats develop neointimal hyperplasia after carotid angioplasty with increased numbers of monocytes, and elderly humans with carotid stenosis have increased numbers of circulating monocytes. These preliminary results may suggest a role for monocytes in the response to carotid angioplasty.
颈动脉血管成形术与老年患者的不良事件有关；尚不清楚这是否与炎症轴改变有关。年轻（6 个月）或年老（22-24 个月）Fisher344 大鼠的颈动脉接受球囊损伤。年老大鼠的管腔面积减少（0.18 ± 0.03 对 0.24 ± 0.01mm²，p =.02），新生内膜增厚增加（0.15 ± 0.04 对 0.08 ± 0.03mm²，p =.006）。年老大鼠的循环单核细胞增加（96 ± 21 对 54 ± 7；p =.002），血管成形术后部位的单核细胞数量也增加。血管成形术后，年老大鼠持续表达单核细胞趋化蛋白-1，但年轻大鼠没有。年老动脉还表现出血管舒张功能缺陷和 eNOS 定位异常。患有严重颈动脉狭窄的高龄（≥80 岁）患者的单核细胞数量（9.1% ± 0.4%）高于较年轻（65-80 岁）患者（8.1% ± 0.3%，p =.013）。年老大鼠在颈动脉血管成形术后发生新生内膜增生，单核细胞数量增加，而颈动脉狭窄的老年患者循环单核细胞数量增加。这些初步结果可能表明单核细胞在颈动脉血管成形术反应中起作用。
