[马钱子生物碱提取物脂质体的制备与表征]
[Preparation and characterization of niosomes of Semen Strychni alkaloids extract].
作者信息
Hu Jie, Wu Zhenzhen, Hu Kefei, Zhang Weihua, Zhang Baoxian
机构信息
Institute of Beijing Increase Biological Products, Beijing 102209, China.
出版信息
Zhongguo Zhong Yao Za Zhi. 2011 Jul;36(14):1955-8.
OBJECTIVE
To prepare a noisome formulation of Semen Strychni alkaloids extract with high encapsulation efficiency.
METHOD
S. Strychni alkaloids were encapsulated into niosomes by pH gradient loading method. The factors influencing on the encapsulation efficiency were investigated, and formulation and preparation process of niosomes were optimised and validated.
RESULT
When the drug to lipid weight ratio was under 1: 10, pH gradient in buffer solution of citric acid at 50 degrees C was more than 4.0, the niosomes (mean diameter 179.2 nm and Zeta potential -25.41 mV) were formed with encapsulation efficiency of over 86.9%.
CONCLUSION
The pH gradient loading method was reliable for preparing niosomes of Semen Strychni alkaloids extract.
目的
制备具有高包封率的马钱子生物碱提取物的恶臭制剂。
方法
采用pH梯度加载法将马钱子生物碱包封于非离子表面活性剂囊泡中。考察影响包封率的因素，优化并验证非离子表面活性剂囊泡的处方和制备工艺。
结果
当药物与脂质重量比低于1:10，50℃柠檬酸缓冲溶液中的pH梯度大于4.0时，形成的非离子表面活性剂囊泡（平均直径179.2nm，Zeta电位-25.41mV）包封率超过86.9%。
结论
pH梯度加载法制备马钱子生物碱提取物非离子表面活性剂囊泡是可靠的。
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