载阿匹吉明纳米结构脂质载体的制备及其体外特性研究
[Preparation and in vitro characterization of apigemin-loaded nanostructured lipid carriers].
作者信息
Zhai Ying-jie, Guo Chen-yu, Hou Jin-ning, Zhang Wei-dong, Zhai Guang-xi
机构信息
College of Pharmacy, Shandong University, Jinan 250012, China.
出版信息
Zhong Yao Cai. 2011 Jun;34(6):962-5.
OBJECTIVE
To prepare Apigemin-loaded nanostructured lipid carriers (Api-NLCs) and evaluate their characteristics.
METHODS
Api-NLCs were prepared by the method of emulsion evaporation-solidification at low temperature. The physicochemical properties such as morphology, size distribution, zeta potential, entrapment efficiency, drug loading and drug release in vitro were evaluated.
RESULTS
The obtained nanoparticles were spherical under transmission electron microscope. The mean diameter was 212.1 nm, the zeta potential was - 14.65 mV, the mean entrapment efficiency was 82.4% and the mean drug loading was 0.97%. The total drug release was 30% in 2 hours followed by a slow and sustained release in vitro.
CONCLUSION
The optimal Api-NLCs show stable characteristics and broad prospects for application.
目的
制备载阿匹吉明的纳米结构脂质载体（Api-NLCs）并评估其特性。
方法
采用低温乳化蒸发固化法制备Api-NLCs。评估其形态、粒径分布、ζ电位、包封率、载药量及体外药物释放等理化性质。
结果
透射电子显微镜下观察所得纳米粒呈球形。平均粒径为212.1 nm，ζ电位为-14.65 mV，平均包封率为82.4%，平均载药量为0.97%。2小时内药物总释放率为30%，随后在体外缓慢持续释放。
结论
优化后的Api-NLCs表现出稳定的特性和广阔的应用前景。
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