台湾汉族人群中二恶英受体复合物成分和解毒相关基因的多态性共同赋予了晚期子宫内膜异位症易感性。
Polymorphisms of dioxin receptor complex components and detoxification-related genes jointly confer susceptibility to advanced-stage endometriosis in the taiwanese han population.
机构信息
Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan Department of Obstetrics and Gynecology, Changhua Christian Hospital, Changhua, Taiwan.
出版信息
Am J Reprod Immunol. 2012 Feb;67(2):160-8. doi: 10.1111/j.1600-0897.2011.01077.x. Epub 2011 Oct 21.
PROBLEM
To establish a multilocus model for studying the effect of dioxin receptor complex components and detoxification-related enzymes on advanced endometriosis.
METHOD OF STUDY
Six single-nucleotide polymorphisms (SNPs) and two deletion polymorphisms from eight genes (CYP1A1, CYP1B1, GSTM1, GSTT1, GSTP1, AhR, ARNT, and AhRR) were genotyped.
RESULTS
In the single SNP analysis, GSTM1 null type and AhRR variant type were associated with a significantly increased risk of endometriosis [odds ratio (OR)=2.38 and 2.45, respectively]. Using multiple SNPs in the logistic regression for covariates, wild-type AhR and mutant AhRR combination was significantly higher in patients (67.8%) than in controls (48.0%) (OR=2.76). On the other hand, mutant AhRR in combination with GSTM1 null genotype was significantly higher in patients (35.5%) than in controls (19.3%) (OR=6.12).
CONCLUSION
Polymorphisms of dioxin receptor complex components and detoxification-related genes jointly confer susceptibility to advanced-stage endometriosis in the Taiwanese Han population.
问题
建立多基因座模型，研究二恶英受体复合物成分和解毒相关酶对晚期子宫内膜异位症的影响。
方法
对来自 8 个基因（CYP1A1、CYP1B1、GSTM1、GSTT1、GSTP1、AhR、ARNT 和 AhRR）的 6 个单核苷酸多态性（SNP）和 2 个缺失多态性进行基因分型。
结果
在单 SNP 分析中，GSTM1 缺失型和 AhRR 变异型与子宫内膜异位症的风险显著增加相关[比值比（OR）分别为 2.38 和 2.45]。在协变量的逻辑回归中使用多个 SNPs，野生型 AhR 和突变型 AhRR 组合在患者（67.8%）中明显高于对照组（48.0%）（OR=2.76）。另一方面，突变型 AhRR 与 GSTM1 缺失基因型的组合在患者（35.5%）中明显高于对照组（19.3%）（OR=6.12）。
结论
二恶英受体复合物成分和解毒相关基因的多态性共同导致台湾汉族人群晚期子宫内膜异位症的易感性。
Zotero 插件