Zheng Neng-neng, Bi Ya-ping, Zheng Ying, Zheng Ruo-heng
Department of Gynecology and Obstetrics, Tongde Hospital of Zhejiang Province, Hangzhou, Zhejiang, 310012, China.
J Assist Reprod Genet. 2015 Jul;32(7):1135-44. doi: 10.1007/s10815-015-0505-3. Epub 2015 Jun 23.
Several studies have suggested an association between the polymorphisms AhR Arg554Lys, AhRR Pro185Ala, and ARNT Val189Val and endometriosis, but results have been inconclusive. The aim of the present study was to assess these associations by meta-analysis.
Eligible literatures were retrieved from PubMed, ISI Web of Science, Elsevier Science Direct, and several Chinese databases. The pooled odds ratios (ORs) and the corresponding 95 % confidence intervals (CIs) were calculated with a random or fixed-effect model.
A total of six eligible studies were included. Regarding the AhR Arg554Lys and ARNT Val189Val polymorphisms, no obvious associations were found in either overall analysis or subgroup analysis based on the country, source of control, sample size, and genotyping method. For the AhRR Pro185Ala polymorphism, overall results suggested a marginal association with endometriosis susceptibility under the dominant model (OR = 1.65, 95 % CI = 1.00-2.72). Furthermore, a significantly increased risk for endometriosis was found in the subgroups which used the TaqMan method for genotype analysis or had a sample size ≥200.
This meta-analysis suggested that the polymorphisms of AhR Arg554Lys and ARNT Val189Val are not associated with endometriosis, while the AhRR Pro185Ala polymorphism may be associated with endometriosis risk. However, further case-control studies with larger sample sizes are needed to confirm our results.
多项研究表明芳烃受体（AhR）基因Arg554Lys多态性、芳烃受体阻遏蛋白（AhRR）基因Pro185Ala多态性和芳香烃受体核转运蛋白（ARNT）基因Val189Val多态性与子宫内膜异位症之间存在关联，但结果尚无定论。本研究旨在通过荟萃分析评估这些关联。
从PubMed、ISI Web of Science、爱思唯尔科学Direct以及几个中文数据库中检索符合条件的文献。采用随机或固定效应模型计算合并比值比（OR）及相应的95%置信区间（CI）。
共纳入6项符合条件的研究。对于AhR Arg554Lys和ARNT Val189Val多态性，在基于国家、对照来源、样本量和基因分型方法的总体分析或亚组分析中均未发现明显关联。对于AhRR Pro185Ala多态性，总体结果表明在显性模型下与子宫内膜异位症易感性存在边缘关联（OR = 1.65，95%CI = 1.00 - 2.72）。此外，在使用TaqMan方法进行基因分型分析或样本量≥200的亚组中，发现子宫内膜异位症风险显著增加。
本荟萃分析表明，AhR Arg554Lys和ARNT Val189Val多态性与子宫内膜异位症无关，而AhRR Pro185Ala多态性可能与子宫内膜异位症风险相关。然而，需要进一步开展更大样本量的病例对照研究来证实我们的结果。
