肿瘤发生、化疗和放疗耐药中的分化途径。
Differentiation pathways in carcinogenesis and in chemo- and radioresistance.
机构信息
Department of Clinical and Molecular Pathology, Palacky University , Czech Republic.
出版信息
Neoplasma. 2012;59(1):6-17. doi: 10.4149/neo_2012_002.
PMID:22017591
Abstract
Cancer stem cells (CSCs) share many features with embryonic stem cells (ESCs) such as the ability for self-renewal and differentiation. Signaling pathways that are involved in these processes are also involved in chemo- and radioresistance (e.g. Wnt, Notch and Hedgehog pathways). This review is focused on the influence of three important differentiation pathways on carcinogenesis and on chemo- and radioresistance in ESCs and CSCs.
摘要
癌症干细胞（CSCs）与胚胎干细胞（ESCs）具有许多相似的特征，例如自我更新和分化的能力。参与这些过程的信号通路也参与了化疗和放疗抵抗（例如 Wnt、Notch 和 Hedgehog 通路）。本文重点介绍了三种重要的分化途径对 ESCs 和 CSCs 癌发生和化疗及放疗抵抗的影响。
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