Graduate School of Biological Sciences, Nara Institute of Science and Technology, Takayama, Ikoma, Nara, Japan.
Int Rev Cell Mol Biol. 2011;291:227-61. doi: 10.1016/B978-0-12-386035-4.00007-0.
The cell cycle is driven by the activity of cyclin-dependent kinase (CDK)-cyclin complexes. Therefore, internal and external signals converge on the regulation of CDK-cyclin activity to modulate cell proliferation in specific developmental processes and under various environmental conditions. CDK-cyclin activity is fine-tuned by multiple mechanisms, for example, transcriptional control, protein degradation, phosphorylation, and binding to CDK inhibitor. These molecular mechanisms underlie the regulation of the entry into or the exit from the cell cycle, the rate of cell cycle, or the transition from the mitotic cell cycle to the endocycle. The multiple mechanisms regulating CDK-cyclin activity coordinately enable the elaborate control of cell cycle by various upstream signals. Here, we review the molecular mechanisms that regulate the cell cycle and the endocycle in plants. We also introduce the recent progress in elucidating the regulatory mechanisms underlying plant development and the stress response in terms of cell-cycle control.
细胞周期由细胞周期蛋白依赖性激酶（CDK）-细胞周期蛋白复合物的活性驱动。因此，内部和外部信号汇聚到 CDK-细胞周期蛋白活性的调节上，以在特定的发育过程中和各种环境条件下调节细胞增殖。CDK-细胞周期蛋白活性通过多种机制进行微调，例如转录控制、蛋白质降解、磷酸化和与 CDK 抑制剂的结合。这些分子机制是细胞周期进入或退出、细胞周期速度或有丝分裂细胞周期向内细胞周期过渡的调节基础。调节 CDK-细胞周期蛋白活性的多种机制协调了各种上游信号对细胞周期的精细控制。在这里，我们综述了调节植物细胞周期和内细胞周期的分子机制。我们还介绍了阐明细胞周期调控在植物发育和应激反应中的调控机制方面的最新进展。
