Fridman W H, Michon J
INSERM Unité 255, Institut Curie, Paris, France.
Leuk Res. 1990;14(8):675-7. doi: 10.1016/0145-2126(90)90092-n.
Beside their therapeutic effects, cytokines are involved in pathologies such as IL-6 in myeloma tumor growth and bone resorption, BCGF in the proliferation of hairy cell leukemic cells, IL-2 in the capillary leak syndrome. For biotherapy to develop, it is necessary to understand both the beneficial and the deletorious effects of cytokines.
除了其治疗作用外，细胞因子还参与多种病理过程，如白细胞介素-6参与骨髓瘤肿瘤生长和骨吸收，B细胞生长因子参与毛细胞白血病细胞的增殖，白细胞介素-2参与毛细血管渗漏综合征。为了发展生物疗法，有必要了解细胞因子的有益和有害作用。
