Department of Anesthesiology, Texas Tech University Health Sciences Center, Lubbock, Texas 79430, USA.
Pain Pract. 2012 Apr;12(4):315-25. doi: 10.1111/j.1533-2500.2011.00510.x. Epub 2011 Oct 24.
There exists substantial evidence that a peridural membrane (PM) is present in the spinal canal of humans and, like the pleura and peritoneum, has one or more physiologic functions. Innervation of the PM suggests that it may become a source of pain if injured. Although debated, the physiology of this structure has important implications with respect to neuraxial distribution of drugs and for back and radiating pain. This review, separated into embryological, anatomic, and physiologic discussions, provides an in-depth summary of the observations of this connective tissue. The discrepancies between accounts are highlighted within each section. Focused research to clearly elucidate the true nature of the PM, especially as related to neuraxial distribution of drugs and back and radiating pain, is warranted.
有大量证据表明，硬膜外膜（PM）存在于人类椎管中，并且与胸膜和腹膜一样，具有一种或多种生理功能。PM 的神经支配表明，如果受伤，它可能成为疼痛的来源。尽管存在争议，但该结构的生理学对药物的神经轴分布以及背部和放射痛具有重要意义。本综述分为胚胎学、解剖学和生理学讨论，对这种结缔组织的观察结果进行了深入总结。在每个部分中都突出了说明之间的差异。需要进行有针对性的研究来清楚阐明 PM 的真实性质，特别是与药物的神经轴分布以及背部和放射痛的关系。
