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干细胞与乳腺癌,我们目前处于什么阶段?文献综述

Stem cells and breast cancer, where we are? A concise review of literature.

作者信息

Sanguinetti A, Bistoni G, Avenia N

机构信息

University of Perugia, Peruglia, Italy.

出版信息

G Chir. 2011 Oct;32(10):438-46.

Abstract

There is an analogy between embryogenesis and cancer and the attention is on increasing the rate of cell division and on a small percentage of perennial cells . The key to understanding is to be found in the properties of these cells developed in the form of perennial totipotency, multipotency and unipotent. The normal life cycle involves epigenetic mechanisms that are deregulated in cancer cells, these tumor cells appear to belong to deregulation since its progeny. Here is a review of the literature on embryogenesis of the breast, endocrine system interactions Delna the proper development and functioning of the various cell lines and to the importance of cancer stem cells.

摘要

胚胎发生与癌症之间存在相似之处,关注点在于提高细胞分裂速率以及一小部分永久性细胞。理解的关键在于这些以永久全能性、多能性和单能性形式发展的细胞的特性。正常生命周期涉及在癌细胞中失调的表观遗传机制,这些肿瘤细胞似乎从其后代起就属于失调状态。以下是关于乳腺胚胎发生、内分泌系统相互作用对各种细胞系正常发育和功能的影响以及癌症干细胞重要性的文献综述。

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