Mascali R, Berguiga M, Delhoum S, Le Loir M, Cochard-Marianowski C, Cochener B, Gambrelle J
Service d'Ophtalmologie, CHU Brest, 5, avenue Foch, 29609 Brest cedex, France.
J Fr Ophtalmol. 2012 Jan;35(1):35-9. doi: 10.1016/j.jfo.2011.04.020. Epub 2011 Oct 22.
Endogenous bacterial endophthalmitis (EBE) is an intraocular bacterial infection transmitted via a hemotogenous route, usually occuring in immunocompromised patients with bacteremia spreading from extraocular foci of infection. We report a case of EBE secondary to a dental infection occurring in an immunocompetent patient.
A 61-year-old-man with no past medical history other than a dental bridge on the 13th tooth was referred for rapid onset hypertensive fibrinous panuveitis of the right eye. He presented with profound visual loss in this eye, an absent pupillary reflex and an obscured fundus. The left eye was normal. Neither fever nor constitutional symptoms were noted at presentation. Work-up revealed a mild inflammatory syndrome with increased C-reactive protein, a high antistreptolysin O titer, and an abscess of the dental bridge. The clinical picture worsened rapidly, suggesting the possibility of EBE secondary to an organism of dental origin. Aqueous humor polymerase chain reaction (PCR) was positive for streptococci, which could not be identified more specifically. Removal of the dental bridge in combination with systemic and intravitreal multiple antiobiotic therapy achieved a rapid cure of the EBE. Vitrectomy combined with phacoemulsification was performed later in order to clear media opacities. At 6 months follow-up, best-corrected visual acuity was 8/10 with no recurrent inflammation.
This case shows that EBE can occur in the absence of predisposing factors but with an extraocular infectious focus as simple as a dental abscess. In the absence of associated septicemia, with the involved tooth superior and ipsilateral to the affected eye, a spread of the infection by retrograde venous flow should be suspected. The prognosis for visual function may be good if early diagnosis and immediate treatment can be provided.
内源性细菌性眼内炎(EBE)是一种通过血行途径传播的眼内细菌感染,通常发生在免疫功能低下且有菌血症从眼外感染灶扩散的患者中。我们报告一例发生在免疫功能正常患者中的继发于牙科感染的EBE病例。
一名61岁男性,除第13颗牙有牙桥外无既往病史,因右眼迅速出现高血压性纤维蛋白性全葡萄膜炎前来就诊。他右眼视力严重丧失,瞳孔反射消失,眼底模糊不清。左眼正常。就诊时未发现发热或全身症状。检查发现有轻度炎症综合征,C反应蛋白升高,抗链球菌溶血素O滴度高,且牙桥处有脓肿。临床症状迅速恶化,提示可能是继发于牙科源性病原体的EBE。房水聚合酶链反应(PCR)检测链球菌呈阳性,但无法更具体地鉴定。拔除牙桥并结合全身及玻璃体内多种抗生素治疗使EBE迅速治愈。后来进行了玻璃体切割联合超声乳化术以清除介质混浊。随访6个月时,最佳矫正视力为8/10,无炎症复发。
该病例表明,EBE可在无诱发因素但存在如牙脓肿这样简单的眼外感染灶时发生。在无相关败血症的情况下,若受累牙齿位于患眼上方且同侧,应怀疑感染通过逆行静脉血流扩散。如果能早期诊断并立即治疗,视觉功能预后可能良好。